Although bone grafting has a well-recognised role in orthopaedic surgery for the treatment of nonunion, bridging diaphyseal defects and filling metaphyseal defects, it is associated with postoperative pain and morbidity. When extensive grafting is required, as in spinal arthrodesis and the management of large bony defects, inadequate amounts of autologous bone may not be available. Allograft bo...

Successful bone repair is judged in achieving restitution of space and mechanical integrity, and in regaining function. When the biology or anatomy are insufficient to attain a full repair, therapeutic use of graft material has been used to omit compliance features such as strain tolerance, reduced stiffness, and attenuated strength, and instead promote primary or membranous-type bone formation...

background: bone loss is one of the hallmarks of periodontitis. hence, a major focus of research into periodontal regeneration has concentrated on the initiation of osteogenesis. osteoinduction requires the differentiation of mesenchymal cells into osteoblasts with subsequent formation of new bone. the present study has been carried out to evaluate periodontal bone regeneration in intrabony def...

Hydroxyapatite (HA) is widely applied as bone graft material due to its osteoconductive potential and well-established biocompatibility. In this work, macroporous hydroxyapatite structures made through foaming of aqueous suspensions and gelcasting were tested for in vivo osteointegration. These foams are composed of a three-dimensional array of spherical pores with diameters of approximately 10...

Alteration of the geometrical surface configuration of cortical bone allografts may improve incorporation into host bone. A porous biodegradable coating that would maintain immediate structural recovery and subsequently allow normal graft healing and remodeling by promoting bony ingrowth could provide an osteoconductive surface scaffold. We investigated the feasibility of augmenting cortical bo...