osteoarthritis (oa) a common disease of aged population and one of the leading causes of disability. incidence of knee oa is rising by increasing average age of general population. age, weight, trauma to joint due to repetiting movements in particular squatting and kneeling are common risk factors of knee oa. several factors including cytokines, leptin, and mechanical forces are pathogenic fact...

    Background: Hip osteoarthritis (OA) is a major cause of pain and disability that results in considerable social and medical costs. Mechanics such as posture, alignment and orientation of the hips and the spinal column and the relationship between these factors have been implicated in the development of both hip and spine pathologies. This study aims to test the hypothesis if pelvic incidenc...

conclusions it can be concluded that due to some bioactive and nutrient factors, mscs secretions could be used for recovery of oa as well as prevention of articular cartilage matrix degeneration, using a high dose of cell secretions. results the results revealed a decrease of proteoglycan content in the superficial and intermediate zones and presence of surface fibrillation. therefore, oa induc...

BACKGROUND The matrilin, especially matrilin-3 (MATN3), are reported to play important roles in the pathophysiology of osteoarthritis (OA). To explore the relationship between MATN3 SNP6 (rs8176070) and primary OA, we conducted a community-based case-control study. METHODS A total of 732 community residents aged 40-84 years participated in the community-based study in Northeast China. After t...

Purpose: Total Knee Replacement (TKR) is the treatment of choice for severe osteoarthritis with acceptable outcomes regarding pain management, function and quality of life enhancement. Because many patients require TKR procedure for their both knees, there has always been a challenge in the choice of simultaneous or consecutive operations. The aim of the present study was to compare the t...

Osteoarthritis (OA) a common disease of aged population and one of the leading causes of disability. Incidence of knee OA is rising by increasing average age of general population. Age, weight, trauma to joint due to repetiting movements in particular squatting and kneeling are common risk factors of knee OA. Several factors including cytokines, leptin, and mechanical forces are pathogenic fact...

BACKGROUND Studies have suggested that the symptoms of knee osteoarthritis (OA) are rather weakly associated with radiographic findings and vice versa. Our objectives were to identify estimates of the prevalence of radiographic knee OA in adults with knee pain and of knee pain in adults with radiographic knee OA, and determine if the definitions of x ray osteoarthritis and symptoms, and variati...

BACKGROUND The incidence of knee osteoarthritis (OA) is rising. While several risk factors have been associated with the development of knee OA, this information is not readily accessible to those at risk for osteoarthritis. Risk calculators have been developed for several prevalent chronic conditions but not for OA. Using published evidence on established risk factors, we developed an interact...