OBJECTIVES To evaluate the effect of OSMF on the eustachian tube function and to correlate it with various grades of the disease. STUDY DESIGN Twenty OSMF patients (40 ears) and 20 healthy controls (40 ears) were evaluated for eustachian tube function by eustachian tube function test, tympanometry and audiometry. RESULTS The audiometric and tympanometric analysis showed no significant diffe...

Verrucous carcinoma (VC) otherwise known Ackerman’s tumor is a distinct variety of epidermoid carcinoma with characteristic clinical presentation, behavior and histological features. It usually presents as a hyperplastic epithelium, abundant keratin superficially with a church-spire keratosis and also presenting parakeratin plugging which is characteristic of this VC. Oral squamous cell carcino...

CONTEXT The epithelium atrophy, as the oral submucous fibrosis (OSMF) progresses, is believed to be an after effect of stromal fibrosis, hyalinization, decrease in vascularity and cellularity and is considered as "ischemic atrophy." Due to hypoxia, caspase-3 get activation and subsequent decrease in viable cell count can occur. AIMS AND OBJECTIVES To determine caspase-3 expression in various ...

Background: Oral submucous fibrosis (OSMF) is a chronic disease that produces tissue and considered to be potentially malignant disorder. The exact pathogenesis conversion mechanism of this disorder are still unknown. Myofibroblasts have been implicated as one the possible pathological mechanisms responsible for pathophysiology OSMF. present study was conducted evaluate expression myofibroblast...

OBJECTIVES Oral submucous fibrosis (OSMF) is the most prevalent precancerous condition in India. Low levels of lipids serves as a marker and prognostic indicator in the early detection of oral precancerous and cancerous states. In spite of the high prevalence and its potential to undergo malignant transformation, this condition has not widely been investigated with respect to the serum lipid le...

Introduction: Oral Submucous fibrosis (OSMF) is well recognized as one of the most common potentially malignant disorder of the oral mucosa in India related to chewing of areca nut products and characterized by mucosal rigidity of varying intensity caused by fibroelastic changes of the juxta – epithelial layer, resulting in a progressive inability to open the mouth. Ultrasonography (USG) is a n...

The aim of this study to determine the depth of tumor invasion and pattern of cervical metastasis in patients of OSCC with OSMF. Methods: The authors prospectively investigated 40 patients of OSCC with OSMF who underwent surgery for OSCC with curative intent over a 2 year period. OSCC with OSMF was more commonly seen in males (87.5%) compared to females (12.5%). Buccal mucosa was the most frequ...

BACKGROUND Oral submucous fibrosis (OSMF) is a crippling slowly progressive disease of oral cavity that predominantly affects people habit of consuming areca nut and its commercial preparations which generates high levels of reactive oxygen species (ROS) during their metabolism. OBJECTIVE The objective of this present study is to evaluate the role of oxidative stress in causation and progress...

BACKGROUND Oral submucous fibrosis (OSMF) is a chronic oral mucosal disease characterized by progressive deposition of collagen in subepithelial connective tissue and epithelial atrophy. The present study was conducted to evaluate the changes in epithelial thickness and cellular and nuclear morphometric characteristics of parabasal and spinous compartments of the epithelium in various stages of...

BACKGROUND Oral cancer is the most common cancer in Indian males and is the third most common cancer in Indian females. Tobacco, alcohol, areca nut, and human papillomavirus (HPV) are the common etiologic factors. Each of these agents follows a unique model of carcinogenesis that leads to a certain distinct presentation and behavior. For example, HPV is strongly associated with oropharyngeal ca...