Heledd Havard such as polysaccharide intercellular adhesin (PIA) leads to the creation of a protective extracellular matrix that acts as a physical and electrostatic barrier1. Recruitment, proliferation and maturation follow, resulting in the adhesion and incorporation of other microbes. In its early phase of formation, the structure of the biofilm is susceptible to the host immune system and a...

Orthopedic implant removal is a commonly performed procedure. While implant removal can be associated withimproved symptoms, risks of the surgery are notable. Stripped screws, broken and retained hardware, and morbidityassociated with soft tissue compromise during difficult removal are all common. Familiarity with the instruments iscritical to procedure success. The purpose of...

BACKGROUND Orthopaedic implants such as the total hip or total knee replacement are examples of surgical interventions with postoperative success rates of over 90% at 10 years. Implant failure is associated with wear particles and pain that requires surgical revision. Improving the implant - bone surface interface is a key area for biomaterial research for future clinical applications. Current ...

BACKGROUND Periprosthetic bacterial infections represent one of the most challenging orthopaedic complications that often require implant removal and surgical debridement and carry high social and economical costs. Diabetes is one of the most relevant risk factors of implant-related infection and its clinical occurrence is growing worldwide. The aim of the present study was to test a model of i...

BACKGROUND The aim of this survey study was to evaluate the current opinion and practice of trauma and orthopaedic surgeons in the Netherlands in the removal of implants after fracture healing. METHODS A web-based questionnaire consisting of 44 items was sent to all active members of the Dutch Trauma Society and Dutch Orthopaedic Trauma Society to determine their habits and opinions about imp...

The American Academy of Orthopaedic Surgeons (AAOS) and the American Dental Association (ADA), along with 10 other academic associations and societies recently (December 2012) published their mutual clinical practice guideline "Prevention of Orthopaedic Implant Infection in Patients Undergoing Dental Procedures." This evidence-based guideline ,detailed in 325 pages, has three recommendations an...

The loss of bone integrity can significantly compromise the aesthetics and mobility of patients and can be treated using orthopaedic implants. Over the past decades; various orthopaedic implants; such as allografts; xenografts and synthetic materials; have been developed and widely used in clinical practice. However; most of these materials lack intrinsic osteoinductivity and thus cannot induce...

Surfaces of medical implants can be enhanced with the favorable properties of titanium-nitride (TiN). In a review of English medical literature, the effects of TiN-coating on orthopaedic implant material in preclinical studies were identified and the influence of these effects on the clinical outcome of TiN-coated orthopaedic implants was explored. The TiN-coating has a positive effect on the b...

Orthopaedic and dental implant materials rely heavily on their ability to integrate with bone tissue for successful clinical outcomes, where osseointegration refers to the direct bonding between titanium implants and bone [1]. Evaluating osseointegration, particularly at early time points, presents a variety of challenges. In order to correlate the bone growth mechanisms at implant surfaces to ...