While azolate anions have been extensively used as anionic linkers in framework design, we now demonstrate the synthesis of square-grid networks that utilise their cationic analogues, imidazolium ions, as linkers. The resulting imidazolium frameworks are direct hydrogen-bonded analogues of square-grid metal azolates and the first examples of an inverted polarity framework design based on anioni...

The use of sulfurand selenium-based linkers in polymer-supported organic synthesis (PSOS) is reviewed. The literature describing the application of sulfur-based linkers in the PSOS of small molecules and combinatorial library preparation from 2000 to the present is summarized. The development and use of selenium-based linkers in PSOS, highlighting the work of the Nicolaou and Huang groups, is a...

Recent advances in protein engineering have come from creating multi-functional chimeric proteins containing modules from various proteins. These modules are typically joined via an oligopeptide linker, the correct design of which is crucial for the desired function of the chimeric protein. Here we analyse the properties of naturally occurring inter-domain linkers with the aim to design linkers...

Polyelectrolyte hydrogels play an important role in tissue engineering and can be produced from natural polymers, such as the glycosaminoglycan hyaluronan. In order to control charge density and mechanical properties of hyaluronan-based hydrogels, we developed cross-linkers with a neutral or positively charged triazole core with different lengths of spacer arms and two terminal maleimide groups...

The fracture mechanism of zeolitic imidazolate framework (ZIF) glasses is revealed to be associated with bond switching organic linkers around central Zn nodes. more pronounced for ZIF smaller linkers.

Structural diversity of metal-organic frameworks (MOFs) has been largely limited to linkers with at most two different types of coordinating groups. MOFs constructed from linkers with three or more nonidentical coordinating groups have not been explored. Here, we report a robust and porous crystalline MOF, Zn3(PBSP)2 or MOF-910, constructed from a novel linker PBSP (phenylyne-1-benzoate, 3-benz...

Four N-Fmoc protected polyoxyethylene-based amino acid type linkers were designed and synthesized for peptide derivatization in solid phase. Three of them were obtained in a crystalline form. The crystallized linkers can be stored at 4 degrees C for 2 years without significant decomposition. Protocols for biotinylation and fluorescent labeling of peptides in solid phase were developed. The link...