نتایج جستجو برای: orexigenic effect

تعداد نتایج: 1642258  

Journal: Avicenna Journal of Phytomedicine 2017
Abdolreza Norouzy, Amir Houshang Mohammadpour, Atefeh Jafari, Habibollah Esmaily, Hasan Rakhshandeh, Leila Etemad, Michael Patterson, Mohsen Mazidi, Mohsen Nematy, Sara Baghban,

Objective: Achillea millefolium (A. millefolium) is known as an orexigenic herb in Iranian traditional medicine. In this study, the possible orexigenic effect of hydro-alcoholic extract of A. millefolium was investigated by measuring plasma ghrelin level.Materials and Methods: Thirty male Wistar rats were divided into five groups. Control group received water. Treatment groups received 50, 100 ...

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Journal: :American journal of physiology. Regulatory, integrative and comparative physiology 2009
Csilla Becskei Thomas A Lutz Thomas Riediger

Fasting activates orexigenic neuropeptide Y neurons in the hypothalamic arcuate nucleus (ARC) of mice, which is reversed by 2 h refeeding with standard chow. Here, we investigated the contribution of diet-derived macronutrients and anorectic hormones to the reversal of the fasting-induced ARC activation during 2 h refeeding. Refeeding of 12-h-fasted mice with a cellulose-based, noncaloric mash ...

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Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2013
Guo-Qing Chang Olga Karatayev Sarah F Leibowitz

Animal and clinical studies show that gestational exposure to nicotine increases the propensity of offspring to consume nicotine, but the precise mechanism mediating this behavioral phenomenon is unclear. The present study in Sprague Dawley rats examined the possibility that the orexigenic peptide systems, enkephalin (ENK) and orexin (OX), which are stimulated by nicotine in adult animals and p...

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Journal: :The Journal of pharmacology and experimental therapeutics 2012
Lenka Maletínská Miroslava Pýchová Martina Holubová Miroslava Blechová Zuzana Demianová Tomáš Elbert Blanka Železná

Ghrelin, the only known peripherally produced and centrally acting peptide that stimulates food intake, is synthesized primarily in the stomach and acts through the growth hormone secretagogue receptor (GHS-R1a). In addition to its orexigenic effect, ghrelin stimulates the release of growth hormone (GH). In this study, we investigated the biological properties of full-length and shortened ghrel...

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Journal: :ACS Chemical Neuroscience 2015

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Journal: :Peptides 2008

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Journal: :British Journal of Pharmacology 1999

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Journal: :American journal of physiology. Regulatory, integrative and comparative physiology 2005
Peter Kobelt Johannes J Tebbe Ines Tjandra Andreas Stengel Hi-Gung Bae Viola Andresen Ivo R van der Voort Rüdiger W Veh Christoph R Werner Burghard F Klapp Bertram Wiedenmann Lixin Wang Yvette Taché Hubert Mönnikes

CCK and ghrelin exert antagonistic effects on ingestive behavior. The aim of the present study was to investigate the interaction between ghrelin and CCK administered peripherally on food intake and neuronal activity in specific hypothalamic and brain stem nuclei, as assessed by c-Fos-like immunoreactivity (c-FLI) in nonfasted rats. Ghrelin (13 microg/kg body wt) injected intraperitoneally sign...

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2014
Qian Wang Chen Liu Aki Uchida Jen-Chieh Chuang Angela Walker Tiemin Liu Sherri Osborne-Lawrence Brittany L. Mason Christina Mosher Eric D. Berglund Joel K. Elmquist Jeffrey M. Zigman

The hormone ghrelin stimulates eating and helps maintain blood glucose upon caloric restriction. While previous studies have demonstrated that hypothalamic arcuate AgRP neurons are targets of ghrelin, the overall relevance of ghrelin signaling within intact AgRP neurons is unclear. Here, we tested the functional significance of ghrelin action on AgRP neurons using a new, tamoxifen-inducible AgR...

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Journal: :Diabetes 2013

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