The most definitive, accurate, and reliable method for diagnosing oral mucosal lesions is the scalpel biopsy. The oral brush biopsy coupled with computerassisted analysis (OralCDx, OralScan Laboratories, Inc., Suffern, NY) has been developed as a technique for evaluating unexplained clinically detectable alterations of the surface epithelium of the oral mucosa whether cancer or precancer is sus...

IntRoductIon A biopsy is the removal of part, or all, of a lesion, to enable histopathological examination and definite diagnosis. The word, ‘biopsy’ has been derived from the Greek words, ‘Bios’ (life) and ‘Opsis’ (vision): vision of life. Biopsy is the gold standard diagnostic procedure for obtaining adequate representative tissue for histopathological evaluation, for arriving at a final diag...

IntRoductIon A biopsy is the removal of part, or all, of a lesion, to enable histopathological examination and definite diagnosis. The word, ‘biopsy’ has been derived from the Greek words, ‘Bios’ (life) and ‘Opsis’ (vision): vision of life. Biopsy is the gold standard diagnostic procedure for obtaining adequate representative tissue for histopathological evaluation, for arriving at a final diag...

The conclusions drawn from the study of an oral biopsy are considered essential for the definitive diagnosis of diseases of the oral mucosa, and for the subsequent planning of appropriate treatment. Although the obtainment of biopsies is widely used in all medical fields, the practice is not so widespread in dental practice--fundamentally because of a lack of awareness of the procedure among de...

Proper management of an oral mucosal lesion begins with diagnosis, and the gold standard for diagnosing disease, oral or otherwise, is tissue biopsy. The oral environment, which is moist and confined, poses challenges for collecting a viable tissue sample that will be suitable for diagnosis. These challenges are further compounded by the myriad of biopsy techniques and devices now available. In...

AIMS Squamous Cell Carcinoma (SCC) is the most frequent malignancy of the oral cavity which is known to have a high mortality rate. Early diagnosis of this cancer has a major role in the prevention of its progression and can help increase patient survival. Conventional biopsy is considered the gold standard for diagnosis of oral SCC. However oral brush biopsy is less invasive, quicker and easie...