Abstract The aim of this study was to develop a novel multifunctional nanoparticle, which encapsulates SPION and Gemcitabine in PLGA±PEG to form multifunctional drug delivery system. For this aim, super paramagnetic iron oxide nanoparticles (SPIONs) were synthesized and encapsulated simultaneously with Gemcitabine (Gem) in PLGA±PEG copolymers via W/O/W double emulsification me...

An improved and facile preparation of 3,7-dinitro-1,3,5,7-tetraazabicyclo [3,3,1] nonane(DPT) has been developed starting from urea. In the procedure DPT was synthesized viaN,N’-dinitrourea (DNU) as intermediate and various operating parameters such astemperature, pH and molar ratio of reagents have been optimized to give maximum yield ofthe desired product. The low cost method is concise, oper...

The process parameters, starch-water ratio (A, (w/v) %), pH of suspension (B), Temperature(C, °C) and Time (D, hrs.)., were optimized for the preparation of starch-lysine conjugate and studying their effect on stability of emulsions by calculating emulsion stability index using response surface methodology. The optimized conditions are pH 9.0, temperature 60C, reaction time 6 hrs, starch:water ...

Electrospinning has been recognized as an efficient technique for the fabrication of polymernanofibers. Recently, various polymers have successfully been electrospun into ultrafine fibers.Electrospinning is an extremely promising method for the preparation of tissue engineering scaffolds.In this study, nanofibers gelatin was electrospun at 20% v/v optimized content. To produce...

Introduction: The endemic occurrence of new strains of tuberculosis around the globe has initiated new research on developing diagnostic radiopharmaceutical based on antibiotics. Methods:Tc-99m labeled streptomycin was prepared using freshly milked 99mTcO4- and various concentrations of streptomycin, stannous chloride at various temperatures in high yield radio...

introduction: the endemic occurrence of new strains of tuberculosis around the globe has initiated new research on developing diagnostic radiopharmaceutical based on antibiotics. methods:tc-99m labeled streptomycin was prepared using freshly milked 99mtco4- and various concentrations of streptomycin, stannous chloride at various temperatures in high yield radiochemical purity shown by hplc/rtlc...

In our former work [Catal. Today 174 (2011) 127], 12 heterogeneous catalysts were screened for CO oxidation, and Au-ZnO/Al2O3 was chosen and optimized in terms of weight loading of Au and ZnO. The present study follows on to consider the impact of process parameters (catalyst preparation and reaction conditions), in conjunction with catalyst composition (weight loading of Au and ZnO, and total ...

Applying a simple and selective sample preparation procedure prior to instrumental analysis is the most important and crucial step in an analytical process. Up to now, various sample preparation techniques based on solid phase extraction (SPE) systems have been developed to isolate various types of analytes from different matrices. In the method presented for preconcentration and measurement of...