Aberrations in optical microscopy reduce image resolution and contrast, and can limit imaging depth when focusing into biological samples. Static correction of aberrations may be achieved through appropriate lens design, but this approach does not offer the flexibility of simultaneously correcting aberrations for all imaging depths, nor the adaptability to correct for sample-specific aberration...

We assess the influence of geometric aberrations on optical traps’ in-plane performance by studying the dynamics of trapped colloidal spheres in deliberately distorted holographic optical tweezers. The traps’ lateral stiffness turns out to be insensitive to moderate amounts of coma, astigmatism and spherical aberration. Moreover, holographic aberration correction enables us to compensate inhere...

purpose: to investigate the effects of surface ablation excimer surgery on higher-order aberrations and to assess the safety and efficacy of wavefront-guided surface ablation excimer surgery in patients with hyperopia and hyperopic astigmatism. methods: in this analytical & descriptive study, wavefront-guided surface ablation excimer surgery was performed in 58 eyes of 31 patients with hyperopi...

The eye is an optical instrument that projects scenes of the visual world onto the retina. It has been known for many years that the eye is far from being a perfect optical system, in particular for large pupil diameters. Refractive anomalies (defocus or astigmatism) occur frequently in the eye. In Western countries, myopia affects approximately 30% of the population, although its prevalence is...

PURPOSE To investigate the relations between age and the optical aberrations of the whole eye. The eye's optical quality, as measured by the modulation transfer function (MTF), degrades with age, but the MTF does not provide a means to assess the contributions of individual aberrations, such as coma, spherical aberration, and other higher order aberrations to changes in optical quality. The met...

Recent research demonstrates the advantage of designing electro-optical imaging systems by jointly optimizing the optical and digital subsystems. The optical systems designed using this joint approach intentionally introduce large and often space-varying optical aberrations that produce blurry optical images. Digital sharpening restores reduced contrast due to these intentional optical aberrati...

A Shack-Hartmann aberrometer was used to assess the optical performances of eyes corrected with rigid or soft contact lenses compared with spectacles. Metrics of optical quality derived from the measured wave aberrations were consistent with the subjective rating of visual clarity by subjects. Optical aberration analysis illustrated the differences in aberration structures of eyes wearing diffe...

I read with interest the article of Yu et al.1 about the “Comparison of Visual Quality After SMILE and LASEK for Mild to Moderate Myopia.” The authors compared the aberrations of the small incision lenticule extraction (SMILE) technique versus eyes treated with laser-assisted sub-epithelial keratectomy (LASEK), measuring the aberrations with a dilated pupil at 6 mm. After 3 months of the treatm...

The imaging properties of optical microscopes are often compromised by aberrations that reduce image resolution and contrast. Adaptive optics technology has been employed in various systems to correct these aberrations and restore performance. This has required various departures from the traditional adaptive optics schemes that are used in astronomy. This review discusses the sources of aberra...