The aim of this study was to investigate possible association of a single nucleotide polymorphism (SNP) at position 9250 in exon 7 of the Osteopontin gene (OPN gene 9250) with ankylosing spondylitis (AS). A case–control association study was performed in 120 AS patients and 106 matched controls, consented to participate in the study. OPN gene 9250 polymorphism was detected by polymerase chain r...

Osteopontin (OPN) is an extracellular matrix glycophosphoprotein that plays a key role in the metastasis of a wide variety of cancers. The high level of OPN expression in prostate cells is associated with malignancy and reduced survival of the patient. Recent studies on prostate cancer (PCa) tissue have revealed recurrent genomic rearrangements involving the fusion of the 5' untranslated region...

objective: osteopontin (opn) has been proposed to play a role in bone resorption. with regard to bone and cementum/dentin structural and histological similarities, it was hy-pothesized that expression of this gene might be increased in resorptive lacunae during orthodontic tooth movement. materials and methods: fixed nickel-titanium closed coil springs (dentaurum ® ) capa-ble of delivering appr...

Several genetic loci in the mouse have been identified that regulate the severity of Lyme arthritis. The region of chromosome 5 including the osteopontin (OPN) gene (Opn) has been identified in intercross populations of C3H/HeN x C57BL/6 and C3H/HeJ x BALB/cAnN mice. OPN is of particular interest as it is involved in the maintenance and remodeling of tissue during inflammation, it regulates pro...

background: interfering with cell proliferation and survival is a critical role for antineoplastic drugs leading to cell death through induction of apoptosis. alternative treatments with herbal extracts offer insights into acute myeloid leukemia (aml) therapy. parthenolide (ptl), an extract from feverfew, induces apoptosis in primary human leukemia stem cells (lscs) and bulk leukemic cell popul...

PURPOSE Prostate cancer remains the second most frequent cause of tumor-related deaths in the Western world. Additional markers for the identification of prostate cancer development and progression are needed. Osteopontin (OPN), which activates matrix metalloproteinases (MMP), is considered a prognostic biomarker in several cancers. "In silico" and experimental approaches were used to determine...

BACKGROUND Sarcoidosis is a systemic inflammatory disease of unknown etiology. Osteopontin (SPP1, OPN) is an extra cellular matrix glycoprotein and cytokine with a known role in granuloma formation and in autoimmune and inflammatory diseases. OBJECTIVE To determine whether plasma OPN levels are elevated in patients with sarcoidosis and compare the frequency of four single nucleotide polymorph...

The hematopoietic microenvironment, approximated in vitro by long-term marrow cultures (LTCs), consists of both nonhematopoietic-derived stromal elements and hematopoietic-derived monocyte/macrophages. To better understand the consequences of monocyte-stroma interactions, we compared gene expression profiles of CD14+ peripheral blood monocytes and HS-27a stromal cells cultured alone and togethe...

AIM To investigate the association of Osteopontin (OPN) gene polymorphism and serum thrombin-cleaved OPN level with the susceptibility to ischemic stroke (IS) and its prognosis. METHODS A total of 377 patients with IS and 551 healthy individuals were recruited. The OPN gene polymorphisms at -156 G>GG, -443 C>T and -66 T>G were genotyped. Serum full-length and the thrombin-cleaved OPN were det...

background: acute myeloid leukemia (aml) is an immunophenotypically heterogeneous malignant disease, in which cd34 positivity is associated with poor prognosis. osteopontin (opn) plays different roles in physiologic and pathologic conditions like: survival, metastasis and cell protection from cytotoxic and apoptotic stimuli. due to anti-apoptotic effect of opn in normal and malignant cells, sil...