UNLABELLED Leukoplakia is the most common premalignant lesion of the oral cavity. Epidermal growth factor receptor (EGFR) abnormalities are associated with oral tumorigenesis and progression. We hypothesized that EGFR expression and gene copy number changes are predictors of the risk of an oral premalignant lesion (OPL) progressing to oral squamous cell carcinoma (OSCC). A formalin-fixed, paraf...

AIMS AND OBJECTIVES To study the genotoxic effects of tobacco on the exfoliated buccal epithelial cells in patients with oral precancerous lesions (OPLs) and Patients with tobacco habit but without oral precancerous lesion(habit controls) by using micronucleus assay as well as the quantification and detection of the biomarkers in these premalignant lesions which will be helpful in finding those...

The development and validation of new peptide dihedral parameters are reported for the OPLS-AA force field. High accuracy quantum chemical methods were used to scan φ, ψ, χ1, and χ2 potential energy surfaces for blocked dipeptides. New Fourier coefficients for the dihedral angle terms of the OPLS-AA force field were fit to these surfaces, utilizing a Boltzmann-weighted error function and system...

Single Al wires from unused AAAC (A50) cables were studied after laboratory fatigue testing, which simulated processes arising in these during their operation the of overhead power lines (OPLs) and are valuable for predicting lifespan OPLs. These wires, either fractured testing (maximum loads—149.4–155.9 MPa; number cycles till rupture—83,656–280,863) or remained intact, examined by X-ray diffr...

The distribution of peptide conformations in the membrane interface is central to partitioning energetics. Molecular-dynamics simulations enable characterization of in-membrane structural dynamics. Here, we describe melittin partitioning into dioleoylphosphatidylcholine lipids using CHARMM and OPLS force fields. Although the OPLS simulation failed to reproduce experimental results, the CHARMM s...

Metabolic profiling is widely used as a probe in diagnosing diseases. In this study, the metabolic profiling of urinary carbohydrates was investigated using gas chromatography/mass spectrometry (GC/MS) and multivariate statistical analysis. The kernel-based orthogonal projections to latent structures (K-OPLS) model were established and validated to distinguish between subjects with and without ...

Fish oil is a common source of fat in fish feed production. However, there tendency to substitute with other fats such as lard reduce production costs. Thus, an efficient method for detection highly needed feed’s authenticity. In this study, sn-2 fatty acids (sn-2 FAs) and acid (FA) compositions were incorporated chemometric techniques namely Principal Component Analysis (PCA), Orthogonal Parti...

Objectives: Oral squamous cell cacrcinoma(OSCC) comprises 90% of all oral cancers and 16-62% of OSCC develop from oral premalignant lesions (OPLs). Lymph node metastasis is a major prognostic indicator for OSCC progression. It has been revealed that lymphangiogenic growth factor VEGF-C plays an important role in invasion and nodal metastasis of cancer cells. This study was performed to investig...

Methods Design Case control study. Setting Tertiary paediatric hospital clinic. Population 27 (14F/13M) adolescents with T1D (age (median, interquartile range) 15.5, 14.7-16.4 years; duration 7.7; 6.0-11.8 years; HbA1c 9.1, 8.1-10.1%); glucose 13.35 (7.60-17.85) and 27 (14F/13M) control participants (age 15.1, 14.4-16.8 years). BMI was <95 percentile. Measures Fasting plasma and urine metabolom...