The analgesic and antidiarrhoeal uses of opium were known to the Sumerians and predynastic Egyptians. During 5000 years of medicinal use, opium has become associated with countries, cultures and prominent individuals, and through several modifications, remains an extensively used analgesic and addictive drug. Morphine, the principle active compound in opium, was first isolated by the German che...

during a cross-sectional study, patients who were admitted to the orthopedic department of the urmia university of medical sciences were asked about opium/opioid abuse. demographic characteristics, the pattern of consumption, the substance, the duration of the use, the duration of hospital stay and the cause of their injuries were recorded. among 2,867 patients, 74 (2.5%) patients (71 men and 3...

centuries, both in amedicinal and ‘recreational’ manner. Indeed, findings of fossilized opium poppy seeds dating as far back as 30 000 yr ago suggest the use of opium by Neanderthal man. In 1799, Friedrich Serturner discovered the major active ingredient of opium, which he named morphine and opioid pharmacology was born. Morphine and its derivates are used today for the treatment of acute and c...

BACKGROUND AND OBJECTIVES In addition to their major influence on human behavior, opium and opioids have been used for a long time as sedative and analgesic drugs. As from the 19th century, with the isolation of opium alkaloids and easy parenteral administration of these substances, there has been increased interest in the judicious medical use of opioids and in the analysis of social consequen...

Throughout history, opium has been used as a base for the opioid class of drugs used to suppress the central nervous system. Opium is a substance extracted from the opium poppy (Papaver somniferum L.). Its consumption and medicinal application date back to antiquity. In the medieval period, Avicenna, a famous Persian scholar (980-1037 AD) described poppy under the entry Afion of his medical enc...

N Engl J Med 2003;349:1943-53. Copyright © 2003 Massachusetts Medical Society. pium is a bitter, brown, granular powder derived from the seedpod of the poppy ( Papaver somniferum ). People have used opium for the relief of pain and suffering for thousands of years. Before the 19th century, opium was cultivated and used chiefly in the Middle East, whereas in Europe and the United States it was a...

An opioid is a chemical that binds to opioid receptors, which are widely distributed in the central and peripheral nervous system and gastrointestinal tract. The different effects elicited by activation of these receptors are due to their specific neuronal and extraneuronal distribution. The painkiller effect of opioids is induced by the synergy of the two events, namely reduction of pain thres...

Opium is a drug being used in modern medicine as well as in homeopathy. Despite of the same source, both the pathies have different principles and indications. Opium is an alkaloid having main action on CNS. So in this study, we evaluated the effect of different dilutions of Opium in homeopathic potencies on CNS in mice and compared with that of Pentazocine. We divided forty mice of either sex ...

C describe the concept of multimodal analgesia and give examples Abstract Opium is the natural substance to which modern narcotics owe their existence. First discovered in the 1500s, opium was the most potent analgesic compound in use, held in high regard, hence its Latin name laudanum (to praise). Subsequent studies into the effects of opium led to the discovery of the opioid receptors, and th...