Naltrexone HCl, a long-acting opiate receptor blocker was administered to female hamsters at two doses, 10 and 20 mg/kg, IP prior to 12 hr of nocturnal running or every 12 hr during access to hypothalamic self-stimulation to determine whether endogenous opiates played a role in either of these two motivated behaviors. Naltrexone suppressed total running activity and speed, and caused an increas...

The rewarding effects of drugs of abuse are thought to be dependent on the mesocorticolimbic dopamine system, which originates in the ventral tegmental area (VTA) and projects into the nucleus accumbens (NAC) and other forebrain regions. Heroin, by inhibiting GABAergic interneurons in the VTA, induces local dopaminergic activation and release in the NAC terminals. The role of other basic neurot...

abstract the high prevalence of diabetes in iran and other developing countries is chiefly attributed to urbanization. the objectives of the present study were to assess the prevalence of self-reported diabetes and to determine its associated risk factors. this study is a part of the national noncommunicable disease risk factor surveillance, conducted in 31 provinces of iran in 2011. first, 100...

background there is limited evidence on the course of health service costs before and after psychiatric inpatient treatment, which might also be affected by source of cost data. thus, this study examines: i) differences in health care costs before and after psychiatric inpatient treatment, ii) whether these differences vary by source of cost-data (self-report vs. administrative), and iii) predi...

Discrepancies between biological assays and self-report of illicit drug use could undermine epidemiological research findings. Two objectives of the present study are to examine the degree of agreement between self-reported illicit drug use and hair analysis in a community sample of middle-aged men, and to identify factors that may predict discrepancies between self-report and hair testing. Mal...

STUDY OBJECTIVE To explore the impact of de-industrialisation over a 20 year period on working conditions and health among sawmill workers, in the province of British Columbia (BC), Canada. DESIGN AND SETTING This investigation is based on a sample of 3000 sawmill workers employed in 1979 (a year before the beginning de-industrialisation) and interviewed in 1998. The sample was obtained by ra...

Theoretically, low correlations between implicit and explicit measures can be due to (a) motivational biases in explicit self reports, (b) lack of introspective access to implicitly assessed representations, (c) factors influencing the retrieval of information from memory, (d) method-related characteristics of the two measures, or (e) complete independence of the underlying constructs. The pres...

BACKGROUND Scotland's overall health record is comparatively poor for a Western European country, particularly amongst people of working age. A number of previous studies have explored why this might be the case by comparing mortality in Scotland with England and Wales. A study in the 1980s showed that the higher prevalence of deprivation in Scotland accounted for Scotland's excess mortality ri...

BACKGROUND Several instruments are available to assess children's health-related quality of life (HRQoL) based on self reports as well as proxy reports from parents. Previous studies have found only low-to-moderate agreement between self and proxy reports, but few studies have explicitly compared the psychometric qualities of both. This study compares the reliability, factorial validity and con...

The objective of the study was to assess what differences exist between individuals who are dependent on opiates and benzodiazepines and compare to those who are dependent on opiates. A questionnaire was compiled and administered to patients who had been consecutively admitted to an inpatient drug treatment unit. The prevalence of benzodiazepine dependency was 54 per cent [n = 34]. Patients dep...