the mechanism of flow and sediment transport in channel bend is much complex. because of secondary current, the sediment moves away from outer bank toward inner bank and therefore outer bank of the bend is one of best positions for lateral diversion. in this paper, the mechanism of sediment transport was simulated with ssiim software in the u shape channel with lateral intake. in order to verif...

Voltage-gated sodium channels are vital membrane proteins essential for electrical signalling; in humans, they are key targets for the development of pharmaceutical drugs. Here we report the crystal structure of an open-channel conformation of NavMs, the bacterial channel pore from the marine bacterium Magnetococcus sp. (strain MC-1). It differs from the recently published crystal structure of ...

Loop-gating is one of two voltage-dependent mechanisms that regulate the open probability of connexin channels. The loop-gate permeability barrier is formed by a segment of the first extracellular loop (E1) (the parahelix) and appears to be accompanied by straightening of the bend angle between E1 and the first transmembrane domain (TM1). Here, all-atom molecular dynamics simulations are used t...

A numerical experiment is carried out to study the suitability of two-dimensional (2D) depth-averaged modeling for bend-flow simulation, in which the geometry of the studied channel is rectangular. Two commonly used 2D depth-averaged models for bend-flow simulation are considered in this study of which the bend-flow model includes the dispersion stress terms by incorporating the assumption of s...

Flow processes and sediment transport in a channel bend and associated point bar have been studied in modern rivers, theoretical models and physical experiments: however, the relationship between flow process and pointbar morphology has rarely been explained due to the complex nature of open channel flow. Plan-view exposures of an ancient point-bar complex, exposed at the top of the Cretaceous ...

Voltage-gated ion channels are key players in fast neuronal signalling. Detailed knowledge about channel gating is essential for our understanding of channel function in general and of drug action of channels in particular. Despite a number of recent atomic channel structures, the opening of voltage-gated channels is the subject of heated debates. Here we will discuss two of the controversies: ...

Abstract An open channel flume with a central 180-degree bend rigid bed is designed to obtain better understanding of the complex flow pattern around T-shaped spur dike located in sharp bend. The 3-dimensional velocities are measured by using an acoustic Doppler velocimetry under clear-water conditions. This study’s primary objective compare variations mean along variety lengths. In order do so...