Biopsies from volunteers challenged with Cryptosporidium parvum were examined for transforming growth factor b1 (TGF-b1). None of the prechallenge biopsies exhibited TGF-b. Seven of 12 volunteers with oocyst shedding expressed TGF-b versus 2 of 13 volunteers without detected oocysts. The association of TGF-b expression with oocyst excretion and the timing of symptoms suggests that TGF-b mediate...

Cryptosporidium parvum, Tyzzer, 1912 is identified as a common cause of diarrhoea in immunocompetent individuals. In immunocompromised, especially HIV-infected subjects, cryptosporidiosis causes severe chronic diarrhoea. In this study, nitazoxanide (NTZ) was compared for curative activity with sinefungin (SNF) and paromomycin (PRM) in immunosuppressed rats, a screening model for anticryptospori...

Reduced weight gains and feed conversions are major sources of economic losses from avian coccidiosis. Experiments were conducted to determine possible involvement of up-regulation of cyclooxygenase (COX) activity during coccidia infections that might contribute to reduced weight gain. In a series of trials, young (3 to 5 wk of age) cockerels infected with Eimeria acervulina, a duodenal parasit...

Abstract: Coccidiosis is one of the major parasitic diseases of poultry. In this study, to compare the effects of coccidiostatic drugs on fecal oocyst shedding and body weight gain of coccidi-infected broiler chickens, 180 one day old Ross 308 broiler chicks were randomly assigned to four treatments. Each treatment contained 3 replicates of 15 chickens. Treatments 1 and 2 were fed diets supplem...

background: coccidiosis is recognized as the parasitic disease that has the greatest economic impact on poultry production. modern poultry production is largely dependent upon anticoccidials. objectives: the aim of the present study was to determine and compare the efficacy of two chemical anticoccidials (clopidol and diclazuril) on oocyst shedding and their probable effects on growth performan...

Dexamethasone (Dex) treated Severe Combined Immunodeficiency (SCID) mice were previously described as developing digestive adenocarcinoma after massive infection with Cryptosporidium parvum as soon as 45 days post-infection (P.I.). We aimed to determine the minimum number of oocysts capable of inducing infection and thereby gastrointestinal tumors in this model. Mice were challenged with calibr...

Neospora caninum has emerged as a major cause of abortion in cattle in many countries. This paper reviews recent advances in the life cycle and biology of Neospora with the emphasis on bovine neosporosis. The role of the recently discovered oocyst stage of N. caninum in the epidemiology of neosporosis is discussed. Progress made in serologic diagnosis of N. caninum infection is discussed. There...

Background: Coccidiosis is recognized as the parasitic disease that has the greatest economic impact on poultry production. Modern poultry production is largely dependent upon anticoccidials. Objectives: The aim of the present study was to determine and compare the efficacy of two chemical anticoccidials (Clopidol and Diclazuril) on oocyst shedding and their probable effects on growth performan...

A cloned Eimeria acervulina gene (3-1E) was used to vaccinate chickens in ovo against coccidiosis, both alone and in combination with genes encoding interleukin (IL)-1, IL-2, IL-6, IL-8, IL-15, IL-16, IL-17, IL-18, or interferon (IFN)-gamma. Vaccination efficacy was assessed by increased serum anti-3-1E antibody titers, reduced fecal oocyst shedding, and enhanced body weight gain following expe...

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