BACKGROUND Ocular neuromyotonia (ONM) is a disorder characterized by periodic involuntary extraocular muscle contraction that occurs almost exclusively in the setting of prior radiation to the sella or skull base. We present the first case of abducens neuromyotonia associated with oropharyngeal carcinoma. METHODS AND RESULTS We report a case of a 63-year-old patient with abducens ONM occurrin...

INTRODUCTION In home mechanical ventilation (HMV), the mask is a key factor for patient comfort and therapeutic adherence. There is no evidence on the best strategy for choosing the mask in HMV. OBJECTIVE To explore patient preference when prescribing the mask for HMV treatment and assess its relationship with effectiveness. METHODS A prospective study with repeated measures in stable pati...

The nuclear envelope defines the barrier between the nucleus and cytoplasm and features inner and outer membranes separated by a perinuclear space (PNS). The inner nuclear membrane contains specific integral proteins that include Sun1 and Sun2. Although the outer nuclear membrane (ONM) is continuous with the endoplasmic reticulum, it is nevertheless enriched in several integral membrane protein...

Activated carbon (AC) was prepared from date palm leaflets using NaOH activation. AC oxidized concentrated HNO3 to produce activated (ON). Alkylamines including methylamine (M), dimethylamine (DM), ethylamine (E), diethylamine (DE), and diisopropylamine (DIP) were covalently immobilized onto ON ONM, ONDM, ONE, ONDE, ONDIP hydrophobic carbons, respectively. The surface area of (588 m2/g) decreas...

1 A preliminary version of this paper appeared in FOCS 97. Let a text string T of n symbols and a pattern string P of m symbols from alphabet be given. A swapped version T of T is a length n string derived from T by a series of local swaps (i.e., t ← t +1 and t +1 ← t), where each element can participate in no more than one swap. The pattern matching with swaps problem is that of finding all lo...

Nvj1p resides in the outer nuclear membrane (ONM) and binds the vacuole membrane protein Vac8p to form nucleus-vacuole (NV) junctions in Saccharomyces cerevisiae. The induction of NVJ1 expression during starvation results in the sequestration of two additional binding partners, Tsc13p and Osh1p. Here, we map the domains of Nvj1p responsible for ONM targeting and partner binding. ONM targeting r...

The normal distribution of nuclear envelope transmembrane proteins (NETs) is disrupted in several human diseases. NETs are synthesized on the endoplasmic reticulum and then transported from the outer nuclear membrane (ONM) to the inner nuclear membrane (INM). Quantitative determination of the distribution of NETs on the ONM and INM is limited in available approaches, which moreover provide no i...

The nuclear envelope (NE) consists of the outer membrane (ONM) and inner (INM), which are concentric separated by tens nanometers. This structure separates nucleus from cytoplasm hosts various proteins that essential for a variety signaling processes. NE divided into INM ONM proteins, reflecting their preferential location as dictated function. However, live-cell determination distribution acro...