INTRODUCTION: Non-traumatic osteonecrosis of femoral head (ONFH) is an intractable disease. Many ONFH cases develop in association with steroid treatment. We found that single nucleotide polymorphism (SNP) of the ATP binding cassette B1 (ABCB1) gene and Lipoprotein(a) phenotype is related to ONFH (we reported at 50 and 52 Annual Meeting of the ORS). Since multiple factors are involved in the ri...

Steroid-related osteonecrosis of the femoral head (ONFH) may be a disease that results from the abnormal osteogenic/adipogenic differentiation of bone marrow-derived mesenchymal stem cells (BMMSCs). In the present study, we examined the possible use of lithium in an aim to reverse the abnormal osteogenic/adipogenic differentiation of BMMSCs isolated from rats with steroid-related ONFH (termed O...

BACKGROUND Steroid-induced osteonecrosis of the femoral head (ONFH) is the most common clinical nontraumatic ONFH. Once ONFH occurs, it seriously reduces patients' quality of life. The matrix metalloproteinase/tissue inhibitor of metalloproteinase (MMP/TIMP) system was found to play a significant role in the development of ONFH. The aim of this study was to identify the associations between 7 g...

Osteonecrosis of the femoral head (ONFH) is a common hip joint disease, and steroid-induced ONFH accounts for a large number of cases. Here, we examined eight previously-identified single-nucleotide polymorphisms (SNPs) in the MPP2 and MPP9 genes of 285 steroid-induced ONFH patients and 507 healthy controls from northern China to determine whether these SNPs were associated with the risk of dev...

BACKGROUND The etiology of osteonecrosis of femoral head (ONFH) has not been fully elucidated. Increased intravascular coagulation and/or hypofibrinolysis have been proposed as pathogenic mechanisms. Previous reports demonstrated significant association between incidence of ONFH and polymorphisms of genes related with thrombophilia especially in Caucasian subjects. The aim of our study was to e...

INTRODUCTION Osteonecrosis (ON) of the femoral head (ONFH), a debilitating bone disease characterized by cellular death in the bone tissue, can lead to collapse of the architectural bony structure and joint function loss. Although many conditions, such as steroids, alcoholism, coagulation defects, storage diseases, marrow-infiltrating diseases, and some autoimmune diseases, can increase the ris...

Sex determining region Y-box 9 (SOX9) is a key transcription factor involved in cartilage formation during the embryonic development stage and cartilage growth and repair after birth. To explore the roles of polymorphism and expression of the SOX9 gene in the development of osteonecrosis of the femoral head (ONFH), we analyzed the polymorphism of rs12601701 [A/G] and rs1042667 [A/C] and the ser...

BACKGROUND Osteonecrosis of the femoral head (ONFH) is generally characterized as an irreversible disease and tends to cause permanent disability. Therefore, understanding the pathogenesis and molecular mechanisms of ONFH and developing effective therapeutic methods is critical for slowing the progress of the disease. METHODOLOGY/PRINCIPAL FINDINGS In this study, an experimental rabbit model ...

OBJECTIVE The aim of this study was to investigate the association of plasminogen activator inhibitor-1 (PAI-1) 4G/5G gene polymorphism and osteonecrosis of the femoral head (ONFH). METHODS The pooled relative risk ratio (RR) and 95% confidence intervals (95% CI) were calculated using the the RevMan 5.0 software. RESULTS The present study included 969 patients with ONFH and 419 healthy cont...

Osteonecrosis of the femoral head (ONFH) is a progressive and devastating disease with an unclear etiology. During last decades, great progress has been made in ingenious bone tissue engineering for ONFH treatment. In this contribution, we present comprehensive Review to summarize state-of-the-art treating ONFH.