We report that assemblies formed by eight oligopeptides at phospholipid-decorated interfaces of thermotropic liquid crystals (LCs) trigger changes in ordering of the LCs that are dependent on the secondary structures of the oligopeptides (as characterized in situ using infrared-visible sum-frequency spectroscopy).

Spider silk-inspired peptide multiblock hybrid copolymers composed of alternately aligned self-assembling oligopeptides and flexible polypropylene glycol were newly designed for functional nano/microfilm materials.

1. Abstract 2. Introduction 3. Materials and Methods 3.1. Synthesis of polymer substrates containing biomimetic oligopeptides 3.2. In vitro macrophage and FBGC assays 3.3. In vivo cage implantation study 3.4. Statistical analysis 4. Results and Discussions 4.1. In vitro macrophage adhesion and FBGC formation 4.2. In vivo macrophage adhesion and FBGC formation 4.3. Probing the intracellular sign...

Advances in supramolecular assembly have enabled the design and synthesis of functional materials with well-defined structures across multiple length scales. Biopolymer-synthetic hybrid materials can assemble into supramolecular structures with a broad range of structural and functional diversity through precisely controlled noncovalent interactions between subunits. Despite recent progress, th...

IgGs from patients with multiple sclerosis and systemic lupus erythematosus (SLE) purified on MBP-Sepharose in contrast to canonical proteases hydrolyze effectively only myelin basic protein (MBP), but not many other tested proteins. Here we have shown for the first time that anti-MBP SLE IgGs hydrolyze nonspecific tri- and tetrapeptides with an extreme low efficiency and cannot effectively hyd...

The mechanism of self-assembly by short-chain peptides (oligopeptides) – the process which their molecules spontaneously form an ordered structure has received much attention recently. Self-assembling phenylalanine oligopeptides have been particular interest due to potential as effective aid in design new functional materials. This paper considers results SPM study on ability L-alanyl-L-phenyla...

We previously investigated the physiological effect of an ethanol extract of fermented soymilk on rats and clarified that this extract modulated their hepatic lipid metabolism. Although the soy isoflavones and oligopeptides are representative functional components of the ethanol extract, it remained unclear whether these substances share a role in lipid metabolism modulation. Therefore, we atte...

Support Vector Machines (SVMs) which is one kind of learning machines, was applied to predict the specificity of GalNAc-transferase. The examination for the self-consistency and the jackknife test of the SVMs method were tested for the training dataset (305 oligopeptides), the correct rate of self-consistency and jackknife test reaches 100% and 84.9%, respectively. Furthermore, the prediction o...

Short synthetic oligopeptides based on regions of human proteins that encompass functional motifs are versatile reagents for understanding protein signaling and interactions. They can either mimic or inhibit the parent protein's activity and have been used in drug development. Peptide studies typically either derive peptides from a single identified protein or (at the other extreme) screen rand...

1. Samples of portal venous and femoral arterial plasma and mesenteric lymph were collected from unanaesthetized rats before and during the intra-duodenal infusion of high concentrations (100 mmoljl) of glycine or glycine oligopeptides (up to and including tetraglycine). 2. There was a marked increase in the concentration of free glycine, and a small amount of diglycine was detected in all the ...