This MRI study examined the morphology of the olfactory sulcus, a potential marker of early neurodevelopment in 26 patients with bipolar I disorder and 24 matched controls. Bipolar patients had significantly shallower olfactory sulci bilaterally compared to controls, suggesting that neurodevelopmental abnormalities contribute to the neurobiology of bipolar disorder.

Major depressive disorder (MDD) occurs with a high prevalence among mental illnesses. MDD patients experience sadness and hopelessness, with blunted affective reactivity. However, such depressive episodes are also key symptoms in other depressive disorders, like Bipolar Disorder (BPD) or Seasonal Affective Disorder (SAD). Moreover, depressive symptoms can also be found in healthy individuals, b...

Background: Male idiopathic hypogonadotropic hypogonadism (IHH) is a heterogeneous clinical rare genetic disorder that can be divided into two forms: Kallmann syndrome (KS) and olfactory normal IHH (nIHH). Nearly half of unknown pathogenic genes related mechanisms have yet to explored.

Structural and functional changes in the olfactory system are increasingly implicated in the expression of PTSD. Still, very little is known about the neurobiological networks of trauma-related odor sensitivity or how they relate to other objective and subjective measures of olfaction and PTSD. The purpose of this study was to replicate prior findings and further characterize olfactory function...

Background: Addiction as a mental disorder has large adverse effects on brain health. It alters brain structure and deteriorates brain functionality. Impairment of brain cognition in drug addiction is illustrated in many previous works; however, olfactory perception in addiction and in particular the neuronal mechanisms of it are rarely studied. Methods: In this experiment, we recruited 20 he...

OBJECTIVE Previous investigation has revealed stable olfactory identification deficits in neuroleptic-naive patients experiencing a first episode of psychosis, but it is unknown if these deficits predate illness onset. METHOD The olfactory identification ability of 81 patients at ultra-high risk for psychosis was examined in relation to that of 31 healthy comparison subjects. Twenty-two of th...

BACKGROUND: The number of patients presenting with sudden onset and persistant anosmia other olfactory disorders, which is a finding related to coronavirus disease has been increased considerably. In this study, we aimed evaluate the efficacy training in persistent after Covid-19 infection.
 METHODS: Forty-six who applied for loss smell infection still had disorders were included study. Od...

INTRODUCTION Phantosmia is the qualitative disorder of olfaction characterized by the perception of odor, usually unpleasant, when there are no odorants present. It may be described as cacosmic (rotten, decayed, fecal), torquosmic (burned, metallic, chemical-like), or mixed. Phantosmia is a relatively uncommon disorder of olfaction and represents around 10% to 20% of olfactory disorders among t...

Alzheimer's disease (AD) is a common neurodegenerative disorder with the earliest clinical symptom of olfactory dysfunction, which is a potential clinical marker for AD severity and progression. However, many questions remain unanswered. This article reviews relevant research on olfactory dysfunction in AD and evaluates the predictive value of olfactory dysfunction for the epidemiological, path...