UNLABELLED The identification of the molecular network that supports oligodendrocyte (OL) regeneration under demyelinating conditions has been a primary goal for regenerative medicine in demyelinating disorders. We recently described an essential function for TACE/ADAM17 in regulating oligodendrogenesis during postnatal myelination, but it is unknown whether this protein also plays a role in OL...

Terpinen-4-ol, a monoterpene component of the essential oils of several aromatic plants, exhibits antitumor effects. In this study, the antitumor effects of terpinen-4-ol and the cellular and molecular mechanisms responsible for it were evaluated and studied, respectively on human nonsmall cell lung cancer (NSCLC) cells. Our results indicated that terpinen-4-ol elicited a dose-dependent cytotox...

ghestas-ol-atebba , written by noureddin mohammad ben abdollah shirazi, known as noureddin mohammad shirazi, an iranian physician, scholar and persian author in the indian subcontinent in the eleventh century a.h. he has some works such as alfazol-advieh, tebbe-darashekouhi, ghestas-ol-atebba  and etc. his book, ghestas-ol-atebba , has a simple prose and belongs to the saffavi period. this book...

This experiment was conducted to investigate the effects of olive leaf (OL) on immune response and some blood metabolites of broiler chickens. A total of 400 one-day-old broiler chicks (male and female) were randomly assigned to 5 experimental treatments with 4 replicates of 20 birds each. Birds of different treatments were given diets containing 0, 0.25, 0.5, 0.75 and 1% OL powder from 14 to 4...

“Salting out effect” means that the addition of an organic solvent to an aqueous solution of a salt will reduce the solubility of salts and thus induce its precipitation.1 Therefore, the investigations of the physicochemical properties of inorganic salts in organic solvents – water, such as solubility data together with density, refractive index and so on, are of great scientific importance. Va...

We examined the in vitro metabolism of (+)-terpinen-4-ol by human liver microsomes and recombinant enzymes. The biotransformation of (+)-terpinen-4-ol was investigated by gas chromatography-mass spectrometry (GC-MS). (+)-Terpinen-4-ol was found to be oxidized to (+)-(1R,2S,4S)-1,2-epoxy-p-menthan-4-ol, (+)-(1S,2R,4S)-1,2-epoxy-p-menthan-4-ol, and (4S)-p-menth-1-en-4,8-diol by human liver micros...

There are two categories in which educator can deliver open distance learning (ODL) via an internet connection, namely Synchronous Online Learning (OL-sync) and Asynchronous (OL-async). At Universiti Teknologi MARA Cawangan Pulau Pinang (UiTMCPP), lecturers could conduct ODL OL-sync or OL-async due to MCO was enforced on March 18, 2020. Therefore, this study conducted compare the influence of d...

In several application domains (detection systems, telecommunications, video processing, etc.) the applications deal with multidimensional data. These applications are usually embedded and subjected to real-time and resource constraints. The challenge is thus to provide efficient implementations on parallel and distributed architectures. Array-OL has been designed specifically to handle this ki...

The purpose of this study was to determine the necessity of nitric oxide (NO) for hypertrophy and fiber-type transition in overloaded (OL) skeletal muscle. Endogenous NO production was blocked by administering N(G)-nitro-L-arginine methyl ester (L-NAME; 0.75 mg/ml; approximately 100 mg x kg-1 x day-1) in drinking water. Thirty-eight female Sprague-Dawley rats (approximately 250 g) were randomly...

Six nitrogen-, sulfur- and cyclopropane-containing derivatives of cholestanol were examined as inhibitors of growth and sterol biosynthesis in the trypanosomatid protozoan Crithidia fasciculata. The concentrations of inhibitors in the culture medium required for 50% inhibition of growth were 0.32 microM for 24-thia-5 alpha,20 xi-cholestan-3 beta-ol (2), 0.009 microM for 24-methyl-24-aza-5 alpha...