Tooth agenesis in the reduction of tooth number which includes hypodontia, oligodontia and anodontia is caused by disturbances and gene mutations that occur during odontogenesis. To date, several genetic mutations that unlock the causes of non-syndromic tooth agenesis are being discovered; these have been associated with certain illnesses because tooth development involves the interaction of se...

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Beaks are innovative structures characterizing numerous tetrapod lineages, including birds, but little is known about how developmental processes influenced the macroevolution of these important structures. Here we provide evidence of ontogenetic vestigialization of alveoli in two lineages of theropod dinosaurs and show that these are transitional phenotypes in the evolution of beaks. One of th...

Witter K. , I . Mí‰ek: Time Programme of the Early Tooth Development in the Domestic Sheep (Ovis aries, Ruminantia). Acta Vet. Brno 1999, 68: 3-8. The knowledge of a generally valid pattern of odontogenesis is a prerequisite for the identification of diseases and developmental anomalies in the oral cavity of domestic animals and man. The sheep is a very interesting model species for the investi...

Recently we reported ultrastructural observatlons which indicated that matrix vesicles were actual constituents of the intercellular organic matrix during embryonic tooth development (14). It is assumed that many of these matrix vesicles are involved in formative aspects of dentinogenesis or amelogenesis, two primary extracellular processes that occur during embryonic tooth formation The fracti...

Sonic hedgehog (Shh) is an essential signaling peptide required for normal embryonic development. It represents a highly-conserved marker of odontogenesis amongst the toothed vertebrates. Signal transduction is involved in early specification of the tooth-forming epithelium in the oral cavity, and, ultimately, in defining tooth number within the established dentition. Shh also promotes the morp...

regional odontodysplasia (ro) is a rare developmental dental anomaly with an unknown etiology. it is more often seen in girls than boys. treatment of ro depends on the individual case. the aims of treatment should include aiding mastication and speech, improving aesthetics, reducing the psychological impact of the anomaly, allowing normal jaw growth and development, and if possible protection o...