A novel method for estimating a field of orientation distribution functions (ODF) from a given set of DW-MR images is presented. We model the ODF by Cartesian tensor basis using a parametrization that explicitly enforces the positive definite property to the computed ODF. The computed Cartesian tensors, dubbed Cartesian Tensor-ODF (CT-ODF), are symmetric positive definite tensors whose coeffici...

J. S. Campbell, P. Savadjiev, G. B. Pike, K. Siddiqi Montreal Neurological Institute, Montreal, Quebec, Canada, McGill Centre for Intelligent Machines, Montreal, Quebec, Canada Introduction High angular resolution diffusion (HARD) MRI can be used to infer multiple subvoxel fibre directions [1-2], and this information can be used to improve the precision of fibre tractography over that achieved ...

By revealing complex fiber structure through the orientation distribution function (ODF), q-ball imaging has recently become a popular reconstruction technique in diffusion-weighted MRI. In this paper, we propose an analytical dimension reduction approach to ODF maxima extraction. We show that by expressing the ODF, or any antipodally symmetric spherical function, in the common fourth order rea...

Objective: Type 5 phosphodiesterase inhibitors (PDE5i) are efficient drugs used for treatment of erectile dysfunction (ED); however, a large discontinuation rate due to major side effects is reported. The aim of this study was to evaluate the possible improvement of sildenafil (Sild) pharmacokinetics associated to the sublingual administration of the new available oro-dispersible film (ODF), co...

In High Angular Resolution Diffusion Imaging (HARDI), Orientation Distribution Function (ODF) and Ensemble Average Propagator (EAP) are two important Probability Density Functions (PDFs) which reflect the water diffusion and fiber orientations. Spherical Polar Fourier Imaging (SPFI) is a recent model-free multi-shell HARDI method which estimates both EAP and ODF from the diffusion signals with ...

Introduction: Systemic corticosteroids are anti-inflammatory agents with dexamethasone among the most potent in the class. Within (respiratory) allergy, systemic corticosteroids are usually applied in medical emergencies. In these situations, patients may experience physical or logistic problems taking tablets. To fulfil a practical unmet need for outpatients, Dexa ODF, an oral dissolvable film...

High angular resolution diffusion imaging (HARDI) has become an important magnetic resonance technique for in vivo imaging. Current techniques for estimating the diffusion orientation distribution function (ODF), i.e., the probability density function of water diffusion along any direction, do not enforce the estimated ODF to be nonnegative or to sum up to one. Very often this leads to an estim...

By revealing complex fiber structure through the orientation distribution function (ODF), q-ball imaging has recently become a popular reconstruction technique in diffusion-weighted MRI. In this paper, we propose an analytical dimension reduction approach to ODF maxima extraction. We show that by expressing the ODF, or any antipodally symmetric spherical function, in the common fourth order rea...

Abstract Background Furosemide, a diuretic that acts on the loop of Henle, is commonly used to treat congestive heart failure in veterinary medicine. Some owners have difficulty administering oral tablet medication animal patients, which leads noncompliance, especially during long-term administration. Oral disintegrating film (ODF) has advantages easy administration via non-invasive route, rapi...

Due the well-known limitations of diffusion tensor imaging (DTI), high angular resolution diffusion imaging is currently of great interest to characterize voxels containing multiple fiber crossings. In particular, Q-ball imaging (QBI) is now a popular reconstruction method to obtain the orientation distribution function (ODF) of these multiple fiber distributions. The latter captures all import...