The outer domain (OD) of human immunodeficiency virus (HIV)-1 gp120 represents an attractive, if difficult, target for a beneficial immune response to HIV infection. Unlike the entire gp120, the OD is structurally stable and contains the surfaces that interact with both the primary and secondary cellular receptors. The primary strain-specific neutralizing target, the V3 loop, lies within the OD...

Vehicle re-identification using Bluetooth (BT) signal data has emerged as an effective and economical means for collecting traffic data including Origin Destination (OD) information which is crucial for transportation planning. Direct vehicle tracking based on Time-Lapse Aerial Photography (TLAP) is also increasingly used for OD studies. Neither technique has previously been validated, so the o...

Oldenlandia diffusa (OD) is commonly used with various diseases such as cancer, arthritis, and autoimmune disease. Liver cirrhosis is a predominant risk factor for hepatocellular carcinoma (HCC). Here, we show that the therapeutic effect of OD, which was investigated both in vitro and chemically, induced HCC model. OD significantly enhanced apoptosis and antiproliferative activity and reduced m...

Adult offspring of severely diabetic pregnant rats are insulin resistant and display cardiovascular dysfunction. When pregnant they develop mild hyperglycaemia. Diets high in saturated fat have been implicated in the development of cardiovascular disease and vascular dysfunction. In the present study we have determined vascular function in small mesenteric arteries from offspring of normal (OC)...

Traffics of different regions in a city have different Origin-Destination (OD) patterns, which potentially reveal the surrounding traffic context and social functions. In this work, we present a visual analysis system to explore OD patterns of interested regions based on taxi trajectories. The system integrates interactive trajectory filtering with visual OD patterns exploration. Trajectories r...

Primary visual cortex (V1) is the site at which right and left eye pathways are first integrated, leading to a representation of the visual world in depth. The ocular dominance (OD) of individual cortical neurons varies and may be changed by altering visual experience during the developmental critical period. Estimates of OD, commonly used to quantify the right and left eye synaptic inputs, hav...

BACKGROUND The complexity of fibre distributions in tissues is an important microstructural feature, now measurable in vivo by magnetic resonance imaging (MRI) through orientation dispersion (OD) indices. OD metrics have gained popularity for the characterisation of neurite morphology, but they still lack systematic validation. This paper demonstrates a framework for whole-sample histological q...

In oocyte donation (OD) pregnancies, there is a higher level of antigenic dissimilarity between mother and fetus compared with naturally conceived (NC) pregnancies. We hypothesize that a higher degree and/or a different type of immunoregulation is necessary to maintain an uncomplicated OD pregnancy. Different immunological aspects of successful OD pregnancies (n=28) were compared with those of ...

Background The oral selective phosphodiesterase-4 inhibitor roflumilast (ROF) reduces exacerbations in patients with severe COPD. Adverse events (AEs) can cause early ROF discontinuation. Alternative dosing strategies may help patients continue their therapy. Methods In this multicenter, double-blind trial, 1,321 patients with severe COPD were randomized 1:1:1 to 4 weeks' treatment with ROF 2...