The field of ocular drug delivery is one the most interesting and challenging fields for Formulation Scientists or Pharmacists. In ophthalmic in situ gel many polymers are used which form by various mechanisms like pH-sensitive thermo sensitive gel. We can make instead an solution to overcome problem low bioavailability. Some common diseases cured blepharitis, conjunctivitis, keratitis, trachom...

Eye is a critical part of the body that readily available and with damage having direct effects on life an individual. Delivery ocular drugs always remain challenging for healthcare professionals scientists all over world due to challenges dynamic opthalamic environment provides. These involves different barriers like corneal epithelium, stroma, sclera other bio-membranes (static barriers), cho...

Drug delivery in ocular therapeutics is a challenging problem and is a subject of interest to scientists working in the multidisciplinary areas pertaining to the eye. Most ocular diseases are treated by topical drug application in the form of solutions, suspensions and ointment. These conventional dosage forms suffer from the problems of poor ocular bioavailability, because of various anatomica...

With the recent advancement in the field of ocular therapy, drug delivery approaches have been elevated to a new concept in terms of nonionic surfactant vesicles (NSVs), that is, the ability to deliver the therapeutic agent to a patient in a staggered profile. However the major drawbacks of the conventional drug delivery system like lacking of permeability through ocular barrier and poor bioava...

Ocular Drug Delivery has been a key challenge and attractive field for the pharmaceutical scientist due to peerless anatomy physiology of eye. Glaucoma, dry eye syndrome, keratitis, endophthalmitis, trachoma, conjunctivitis are just few conditions that can affect In order accomplish efficient ocular treatment within eye, At point action, an appropriate supply active substances must be given sus...

Article history: Received on: 14/05/2016 Revised on: 09/06/2016 Accepted on: 24/06/2016 Available online: 26/09/2016 Ophthalmic formulations in terms of eye drops are more frequently used formulation for ocular disorders. But unfortunately this mode of drug instillation into the cul-de-sac of eye shows very poor ocular bioavailability (less than 5%). A large number of carrier systems have been ...

Ocular drug delivery is challenging field to pharmaceutical scientists owing to the underlying anatomical, physiological and dynamic constraints put forth by the eye. Nonetheless, there is increasing need to overcome these barriers for the treatment of sight threatening ophthalmic ailments. Novel drug delivery strategies are being explored while intravitreal injections are still a standard trea...

Ocular diseases include various anterior and posterior segment diseases. Due to the unique anatomy and physiology of the eye, efficient ocular drug delivery is a great challenge to researchers and pharmacologists. Although there are conventional noninvasive and invasive treatments, such as eye drops, injections and implants, the current treatments either suffer from low bioavailability or sever...

Environmentally responsive gel formulation for ocular controlled delivery of carteolol hydrochloride (HCl) was developed in an attempt to improve ocular bioavailability and hence decrease its systemic absorption and side effects. The viscosity and the ability of the prepared formulations to deliver carteolol HCl in vitro and in vivo were monitored and compared with an aqueous commercial solutio...

It is well known that ocular bioavailability after topical instillation is extremely low compared with the other administration including oral administration, transdermal application, vitreous injection, and implantable delivery. The ocular bioavailability is also affected by a variety of pharmaceutical factors such as formulation viscosity and the particle size of suspension, and so on. In spi...