Chicken liver synthesizes glucose from lactate and dihydroxyacetone at high rates but pyruvate, glycerol, alanine, and other amino acids are poor glucose precursors. Despite its limited conversion to glucose, 1 m~ pyruvate completely suppressed ketone body synthesis from octanoate by perfused chicken liver, whereas lactate at this concentration had no effect on ketogenesis. Also, increasing the...

Transcription of acetyl-CoA carboxylase in avian liver is low during starvation or after consumption of a low-carbohydrate, high-fat diet and high during consumption of a high-carbohydrate, low-fat diet. The role of fatty acids or metabolites derived from fatty acids in the nutritional control of acetyl-CoA carboxylase transcription was investigated by determining the effects of long- and mediu...

BACKGROUND Compared with short and long chain fatty acids, medium chain fatty acids (MCFAs) have been shown to provide the highest colonic absorption of substrate carbon. Moreover, colonic epithelial cells fulfil their basic energy requirements as easily from MCFAs as from short chain fatty acids. AIMS To further characterise octanoate as a colonic luminal substrate, we determined in vivo the...

sodium salt of n-acetyl-dl-tryptophan (at) and octanoic acid (caprylic acid ca) individually and in combination were studied as thermal stabilizer with different concentrations in heat treatment of human albumin solution. hplc protein profiles before pasteurization of albumin showed less than 1% polymer. in free stabilizer albumin solution during pasteurization visible clot was formed. but by u...

Pyruvate has been shown to decrease the oxidation of palmitic acid by rat liver and kidney slices (l), but to have little influence on octanoate oxidation by liver slices (2, 3). Likewise, prior glucose administration decreased the rate of oxidation of palmitic acid by the rat in viva, but not that of octanoic acid (4). Glucose has also been reported to decrease the oxidation of serum lipides b...

Laninamivir octanoate, a long-acting neuraminidase inhibitor, is an effective treatment for influenza. However, its effectiveness for the prevention of influenza has not yet been demonstrated. We conducted a double-blind, multicenter, randomized, placebo-controlled trial to determine whether laninamivir octanoate was superior to a placebo for post-exposure prophylaxis of influenza in household ...

Active (anti-microbial) packaging was prepared using three different formulations; Auranta FV; Inbac-MDA and sodium octanoate at two concentrations (2.5 and 3.5 times their minimum inhibitory concentration (MIC, the lowest concentration that will inhibit the visible growth of the organisms) against Clostridium estertheticum, DSMZ 8809). Inoculated beef samples were packaged using the active pac...

The conversion of octanoate-l-Cl4 to radioacetoacetate and the effect of pyruvate on this process are dependent on the K+ concentration in the incubation medium (1). These results prompted this investigation in which the incorporation of octanoate-l-Cl4 into fatty acids and cholesterol was determined in the presence of non-radioactive additions of pyruvate, succinate, and fumarate. Malonate was...

The changes of isocitrate lyase levels with respect to the catabolism of triglycerides have been studied during the germination of Pinus pinea seeds. We studied the effects of octanoate, oleate, and inhibitors of protein synthesis on isocitrate lyase during germination. Pyruvate kinase, glucose-6-P-dehydrogenase, malate dehydrogenase, and isocitrate dehydrogenase were also assayed. Octanoate an...

Glucose is the dominant oxidative fuel for brain, but studies have indicated that fatty acids are used by brain as well. We postulated that fatty acid oxidation in brain could contribute significantly to overall energy usage and account for non-glucose-derived energy production. [2,4,6,8-13C4]octanoate oxidation in intact rats was determined by nuclear magnetic resonance spectroscopy. We found ...