Patientinnen und Patienten mit einer Rheumatoiden Arthritis (RA) haben aufgrund der krankheitsbedingten Immundysregulation, immunsuppressiven Therapie sowie weiterer chronischer Begleiterkrankungen ein erhöhtes Infektionsrisiko. Ob sie sich auch häufiger SARS-CoV-2 infizieren als Gesunde ob COVID-19 bei ihnen schwerer verläuft, untersuchte nun US-Forscherteam.

Plasma leptin levels are elevated in obesity suggesting a pathophysiologic role of this hormone in obesity and related disorders, such as hypertension. Furthermore, despite excess leptin levels, leptin satiety action is blunted in obesity suggesting the occurrence of central leptin resistance. As leptin acts on the kidney to induce natriuresis, renal leptin receptor alterations could lead to a ...

Ob-Rb: Long isoform of leptin receptor. Ob-Ra, Ob-RcÖOb-Rf: Short isoforms of leptin receptor. FSH: Follicle stimulating hormone. IGF-I: Insulin-like growth factor type 1. BCL-2: B-cell lymphoma 2. Bax: Bcl-2-associated X protein. DMEM: Dulbecco’s Modified Eagle Medium. ER: Estrogen receptor alpha. ER: Estrogen receptor beta. AR: Androgen receptor. LHR: Luteinizing hormone receptor. FSHR: Folli...

Emerging evidence has suggested a critical role of leptin in hepatic inflammation and fibrogenesis, however, the precise mechanisms underlying the profibrogenic action of leptin in the liver has not been well elucidated. Therefore, the present study was designed to investigate the expression and functions of leptin receptors (Ob-R) in hepatic sinusoidal cells. Hepatic stellate cells (HSCs), Kup...

Leptin, the adipocyte-produced hormone that plays a key role in body weight homeostasis, has recently been found to be involved in the regulation of the hypothalamic-pituitary-adrenal axis. Moreover, reciprocal interactions between leptin and glucocorticoids have been described. In the present communication, two different strategies were undertaken to explore the mode of action of leptin in the...

The association of progressive obliterative bronchiolitis (OB) with rheumatoid arthritis (RA) is uncommon but has been reported previously. Diffuse panbronchiolitis (DPB) is a unique inflammation principally affecting the respiratory bronchioli and has been reported mainly in Japanese adults. Recently, DPB has also been noted in patients with RA in Japan. Therefore, there might be considerable ...

Es besteht ein wachsendes Forschungsinteresse an der Frage, ob eine kurze Therapie den Ausbruch einer rheumatoiden Arthritis (RA) bei Risikopersonen verhindern kann. Neben Ungewissheit zu Wirksamkeit und Sicherheit präventiven Behandlung ist auch das individuelle RA-Risiko, die Zeitspanne, in Risiko Schwere Erkrankung unklar. Simons et al. quantifizierten Präferenzen für präventive Behandlungen...

Patienten mit rheumatoider Arthritis (RA) haben im Durchschnitt ein erhöhtes Risiko für venöse Thromboembolien (VTE). Dies zeigten bereits mehrere vorherige Studien. Unbekannt war bislang, ob und wieweit die Risikoerhöhung der Krankheitsaktivität RA zusammenhängt. Eine landesweite Kohortenstudie aus Schweden klärt auf.

Obliterative (constrictive) bronchiolitis (OB) is a rare disease characterized by destruction of the bronchiolar epithelium and subsequent progressive airway obstruction. OB most common in rheumatoid arthritis (RA) compared to other systemic rheumatic diseases. Clinical manifestations are found mainly with long duration RA absence adequate therapy for articular manifestations. We present clinic...

Background: Several study suggested body mass index(BMI) may influence development of rheumatoid arthritis(RA). There are conflicting reports concerning the impact high BMI on RA, but several obese drug resistance and functional impairment. The relationship genetic polymorphism obesity is unclear in RA. Objectives: To examine among BMI, obesity, disease activity laboratory parameters, therapeut...