نتایج جستجو برای: nucleostemin

تعداد نتایج: 191  

Journal: :Cell Cycle 2010

Journal: :PLoS Genetics 2008
Michelle M. Kudron Valerie Reinke

The nucleolus has shown to be integral for many processes related to cell growth and proliferation. Stem cells in particular are likely to depend upon nucleolus-based processes to remain in a proliferative state. A highly conserved nucleolar factor named nucleostemin is proposed to be a critical link between nucleolar function and stem-cell-specific processes. Currently, it is unclear whether n...

E Babaei M Halimi M.A Hoseinporfeizi S Saed V Montazeri

Background & Aims: Nucleostemin is one of the stem cell enriched proteins which encodes a novel nucleolar GTP-binding protein found at high levels in the adult and embryonic stem (ES) cells but not in terminally differentiated cells. It is also expressed in tumor cell lines as well as in the several types of human cancers. Due to the increasing rate of breast cancer in recent years, in the pres...

Journal: :Molecular biology of the cell 2008
Hanhui Ma Thoru Pederson

Nucleostemin (NS) is expressed in the nucleoli of adult and embryonic stem cells and in many tumors and tumor-derived cell lines. In coimmunoprecipitation experiments, nucleostemin is recovered with the tumor suppressor p53, and more recently we have demonstrated that nucleostemin exerts its role in cell cycle progression via a p53-dependent pathway. Here, we report that in human osteosarcoma c...

2013
E. De Nevi P. Marco-Salazar D. Fondevila,1 E. Blasco L. Pérez M. Pumarola

Finding a marker of neural stem cells remains a medical research priority. It was reported that the proteins doublecortin and nucleostemin were related with stem/progenitor cells in central nervous system. The aim of the present immunohistochemical study was to evaluate the expression of these proteins and their pattern of distribution in canine brain, including age-related changes, and in non-...

Journal: :Journal of cell science 2014
Tao Lin Lingjun Meng Tsung-Chin Lin Laura J Wu Thoru Pederson Robert Y L Tsai

The mammalian nucleolar proteins nucleostemin and GNL3-like (GNL3L) are encoded by paralogous genes that arose from an ancestral invertebrate gene, GNL3. Invertebrate GNL3 has been implicated in ribosome biosynthesis, as has its mammalian descendent, GNL3L. The paralogous mammalian nucleostemin protein has, instead, been implicated in cell renewal. Here, we found that depletion of nucleostemin ...

Journal: :modares journal of medical sciences: pathobiology 2008
parvaneh nikpour seyed mehdi jafarnejad mahdi forouzandeh seyed javad mowla

objective: nucleostemin (ns) is a recently identified gene that is expressed mainly in the nucleoli of neuronal, embryonic and mesenchymal stem cells which plays a role in their self renewal. over expression of this gene has been reported in several cancer cell lines tumoral tissues including gastric, hepatic and prostate cancer. in this study, we investigated the effects of suppression of this...

2011
Jon Gil-Ranedo Marina Mendiburu-Eliçabe Mercedes García-Villanueva Diego Medina Marta del Álamo Marta Izquierdo

Glioblastomas (GBM) may contain a variable proportion of active cancer stem cells (CSCs) capable of self-renewal, of aggregating into CD133(+) neurospheres, and to develop intracranial tumors that phenocopy the original ones. We hypothesized that nucleostemin may contribute to cancer stem cell biology as these cells share characteristics with normal stem cells. Here we report that nucleostemin ...

امینی, صبریه, داوری, بهروز, صوفی مجیدپور, حشمت‌اله, فتحی, فردین, مبلغی, جعفر , نیکخو, بهرام, پریور, کاظم,

  چکید ه   سابقه و هدف   ژن‌هایی که درکنترل خودبازسازی سلول‌های بنیادی نقش دارند به عنوان دسته جدیدی از مارکرهای مولکولی سرطان معرفی شده اند. در این تحقیق، بیان ژن‌های Oct4 ، Sox2 ، Nanog ، Nucleostemin ، Zfx و Bmi-1 در رده‌های سلولی سرطان کولون، پروستات، کبد و مثانه هم چنین در نمونه‌های انسانی این سرطان‌ها مورد بررسی قرار گرفت .   مواد و روش‌ها   در یک مطالعه تجربی، بیان ژن‌های خودبازسازی Oct4...

اسودی کرمانی, ایرج , حسینپور فیضی, محمدعلی, مقترن بناب , نازیلا , موسوی, سیّدمحمدامین ,

 Background & Aims: Acute promyelocytic leukemia (APL) is a malignant hematopoietic disorder caused by indefinite proliferation and lack of differentiation of leukemia stem cells. Elucidation of signaling pathways involved in leukemic stem cells are current strategies in treatment of leukemias. In this content, nucleostemin (NS) plays a critical role in proliferation and self renewal of stem an...

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