Nuclear Polyubiquitinated Proteins to PML Bodies* Serhiy Pankiv, Trond Lamark, Jack-Ansgar Bruun, Aud Øvervatn, Geir Bjørkøy and Terje Johansen From the Molecular Cancer Research Group, Institute of Medical Biology, University of Tromsø, 9037 Tromsø, and Department of Biosciences, University College of SørTrøndelag, Norway Running head: Nucleocytoplasmic shuttling of p62/SQSTM1 Address correspo...

VP19C is a structural protein of herpes simplex virus type 1 viral particle, which is essential for assembly of the capsid. In this study, a nuclear export signal (NES) of VP19C is for the first time identified and mapped to amino acid residues 342 to 351. Furthermore, VP19C is demonstrated to shuttle between the nucleus and the cytoplasm through the NES in a chromosomal region maintenance 1 (C...

Many cellular processes rely on the ordered assembly of macromolecular structures. Here, we uncover an unexpected link between two such processes, endocytosis and transcription. Many endocytic proteins, including eps15, epsin1, the clathrin assembly lymphoid myeloid leukemia (CALM), and alpha-adaptin, accumulate in the nucleus when nuclear export is inhibited. Endocytosis and nucleocytoplasmic ...

Stress induces oscillatory nucleocytoplasmic shuttling of the transcription factor Msn2 in yeast. The subcellular localization of Msn2 is controlled by the cAMP-dependent protein kinase, PKA. Recent experimental observations corroborated by a deterministic computational model for the cAMP-PKA pathway in yeast suggest that the oscillatory dynamics of Msn2 results from the periodic activation of ...