OBJECTIVES To study the outcome of chromosomally normal pregnancies with increased nuchal translucency at the 10-14-week scan. DESIGN Retrospective study of 1320 chromosomally normal singleton pregnancies with nuchal translucency of > or = 3.5 mm. In addition to fetal karyotyping these patients were managed with follow-up scans at 14-16 and 20-22 weeks, specialist fetal echocardiography and i...

The aim of this study was to determine the outcome of chromosomally normal livebirths with increased fetal nuchal translucency at 10-14 weeks' gestation. Clinical follow up of 89 chromosomally normal livebirths that in fetal life had a minimum nuchal translucency thickness of 3.5 mm and a comparison group of 302 infants whose fetal nuchal translucency thickness at 10-14 weeks of gestation was l...

OBJECTIVE To investigate the prevalence of detectable jugular lymphatic sacs in a setting for first trimester screening for Down syndrome, and to evaluate the influence of jugular lymphatic sacs on the screening performance for chromosomal abnormalities. METHODS A prospective single center study (Erasmus University Medical Center, Rotterdam, The Netherlands) over a period of one year (January...

Note: It should be noted that appropriate training of ultrasonographers with ongoing quality assurance programs are considered critical to the accurate measurement of fetal nuchal translucency. In addition, in published studies of first trimester screening, the laboratory and imaging components of screening (i.e., fetal nuchal translucency and measurement of maternal serum factors) are performe...

OBJECTIVE The purpose of this study was to examine the sonographic features of trisomy 13 at 11 to 13(+6) weeks of gestation. STUDY DESIGN This was a retrospective study that examined the features of trisomy 13 at the ultrasound scan at 11 to 13(+6) weeks of gestation, which in our center is performed for the measurement of crown-rump length, nuchal translucency thickness, and fetal heart rat...

BACKGROUND Nuchal translucency (NT) is the fluid collection behind the fetal neck which can be measured by ultrasound at 11-14 weeks of gestation. Increase in the nuchal translucency thickness is associated with various congenital anomalies. OBJECTIVE To study the relationship between nuchal translucency thickness, crown rump length and gestational age in normal fetus. METHODS Prospective a...

CONTEXT The literature shows an association between several ultrasound markers and chromosome abnormality. Among these, measurement of nuchal translucency has been indicated as a screening method for aneuploidy. The trisomy of chromosome 21 has been most evaluated. OBJECTIVE To define the best fixed cutoff point for nuchal translucency, with the assistance of the ROC curve, and its accuracy i...

Johnson, S. (1996). Down’s syndrome screening in the UK, Lancet, 347, 906–907. Pandya, P.P., Snijders, R.J.M., Johnson, S.P., de Loudes Brizot, M., Nicolaides, K.H. (1995). Screening for fetal trisomies by maternal age and fetal nuchal translucency thickness at 10 to 14 weeks of gestation, Br. J. Obstet. Gynaecol., 102, 957–962. Schuchter, K., Wald, N.J., Hackshaw, A.K., Hafner, E., Liebhardt, ...

Objectives: To evaluate and compare the performance of various quality control methods for nuchal translucency (NT) measurements. Methods: Fetal NT measurements performed over a oneyear period in a single center were used for the study. The retrospective quality review methods proposed by the Fetal Medicine Foundation (FMF) and the Woman & Infants Hospital of Rhode Island (WIHRI) were assessed ...

OBJECTIVE To determine the relative contribution of nuchal translucency (NT) to the biochemical detection rates of combined screening for trisomies 13 and 18 in two healthcare systems practicing different quality-control systems of nuchal measurement. METHODS De-identified data collected from the Fetal Medicine Foundation in the United Kingdom and laboratory data from NTD laboratories in the ...