[The NTP] had to be more responsive to critical issues in public health policy. Since its inception in 1978, the National Toxicology Program (NTP) has made considerable progress toward achieving its goal of international prominence based on excellence in toxicological studies. In the early 1990s when we first developed significant interactions with the NTP, we were struck by the reputation of t...

Multi-subunit RNA polymerases bind nucleotide triphosphate (NTP) substrates in the pretranslocated state and carry the dNMP-NTP base pair into the active site for phosphoryl transfer. NTP-driven translocation requires that NTP substrates enter the main-enzyme channel before loading into the active site. Based on this model, a new view of fidelity and efficiency of RNA synthesis is proposed. The...

Non-thermal plasma (NTP) consists of a huge amount of biologically active particles, whereas its temperature is close to ambient. This combination allows one to use NTP as a perspective tool for solving different biomedical tasks, including antitumor therapy. The treatment of tumor cells with NTP caused dose-dependent effects, such as growth arrest and apoptosis. However, while the outcome of N...

BACKGROUND Expression of neuronal thread protein (NTP), which is considered to be related to neuritic sprouting and neuronal death, may be elevated in brain tissue, cerebrospinal fluid, and even urine in patients with Alzheimer's disease (AD). OBJECTIVE In this study, we analyzed the correlation between urine AD-associated NTP (AD7c-NTP) level, and amyloid-β (Aβ) deposition, and clinical symp...

The National Toxicology Program (NTP) Center for the Evaluation of Risks to Human Reproduction (NTP-CERHR) was established by the NTP and the National Institute of Environmental Health Sciences (NIEHS) in 1998 to address the impact of chemical exposures on human reproductive and developmental health and to serve as an environmental and reproductive health resource for government agencies and th...

Dementia in Alzheimer's disease (AD) is ultimately due to cell loss mediated by several mechanisms including, apoptosis, impaired mitochondrial function, and possibly necrosis. A second major neuroanatomic correlate of dementia is aberrant cortical neuritic sprouting with abundant proliferation of dystrophic neurites. Early in vivo detection of AD will require non-invasive assays of highly sens...

Non-thermal plasma (NTP) has been proposed as a novel therapeutic method for anticancer treatment. However, the mechanism underlying its biological effects remains unclear. In this study, we investigated the inhibitory effect of NTP on the invasion of HeLa cells, and explored the possible mechanism. Our results showed that NTP exposure for 20 or 40 s significantly suppressed the migration and i...

Human Services in 1978 to coordinate toxicological testing programs within the department, strengthen the science base in toxicology, and provide information about potentially toxic chemicals to health regulatory and research agencies , the scientific and medical communities, and the public. With more than 80,000 chemicals registered for commercial use in the United States and an estimated 2,00...

Numerous previous studies have pointed out that the South Asia monsoon (SAM) contributes most moisture to southern Tibetan Plateau, whilst over Northern Plateau (NTP) is supplied by westerlies, but sources for extreme precipitation events remain unclear. In this study, tracking of external was performed on ten each six target subregions NTP during summer 2010–2018. We found SAM provided in NTP,...

The Network Time Protocol (NTP) is widely used to synchronize computer clocks throughout the Internet. Existing NTP clients and servers form a very large distributed system, and yet the tools available to observe and manage this system are fairly primitive. This paper describes our experiences with a prototype tool that attempts to discover relevant information about every NTP site on the Inter...