Simple and rapid spectrophotometric & chromatographic methods have been developed and validated for the determination of Darunavir and Ropivacain in tablets and as bulk drug. The methods applied were involing use 1,2-naphthoquinone-4-sulphonate (NQS). The formar was solubilised in an alkaline medium with NQS to form an orange-colored product with λmax at 488 nm while the later gave blue colored...

Abstract From 2016, all Western Australian schools were mandated to implement the National Quality Standard (NQS) in Kindergarten through Year 2. Over first year of implementation, this mandate had varying degrees success adoption. This study examined four which identified as having implemented NQS. A qualitative methodology was employed examine those factors that supported implementation. key ...

ThyX is an essential thymidylate synthase that is mechanistically and structurally unrelated to the functionally analogous human enzyme, thus providing means for selective inhibition of bacterial growth. To identify novel compounds with anti-bacterial activity against the human pathogenic bacterium Helicobacter pylori, based on our earlier biochemical and structural analyses, we designed a seri...

Two simple visible spectrophotometric methods are developed and validated for the quantification of modafinil using 1,2-naphthoquinone-4-sulphonic acid (NQS method) and 2,4-dinitrophenol (DNP method) as analytical reagents. The NQS method involves the reaction of modafinil with 1,2-naphthoquinone-4-sulphonate in alkaline medium at room conditions to form a yellow colored product exhibiting maxi...

two simple visible spectrophotometric methods are developed and validated for the quantification of modafinil using 1,2-naphthoquinone-4-sulphonic acid (nqs method) and 2,4-dinitrophenol (dnp method) as analytical reagents. the nqs method involves the reaction of modafinil with 1,2-naphthoquinone-4-sulphonate in alkaline medium at room conditions to form a yellow colored product exhibiting maxi...

A rapid, simple and sensitive high-performance liquid chromatographic (HPLC) method for determination of Amlodipine (AML) using sodium 1,2-naphthoquinone4-sulfonate (NQS) has been developed. The method is based on the formation of a brown color product from the reaction between AML and NQS. The nucleophilic substitution reaction proceeds quantitatively at pH 13 buffer solution with absorption m...

Naphthoquinones (NQs) occur naturally in a large variety of plants. Several NQs are highly active against protozoans, amongst them the causative pathogens of neglected tropical diseases such as human African trypanosomiasis (sleeping sickness), Chagas disease and leishmaniasis. Prominent NQ-producing plants can be found among Juglans spp. (Juglandaceae) with juglone derivatives as known constit...

Data integration is particularly difficult in neuroscience; we must organize vast amounts of data around only a few fragmentary functional hypotheses. It has often been noted that computer simulation, by providing explicit hypotheses for a particular system and bridging across different levels of organization, can provide an organizational focus, which can be leveraged to form substantive hypot...

A cycle of length 9 of vertices (x1, x2, . . . , x9), in the cyclical order, with the three edges {x1, x4}, {x4, x7}, {x1, x7} is called an NQ-graph or also a nonagon quadruple graph. A nonagon quadruple system, briefly NQS, of order v and index λ is an NQ-decomposition of the complete multigraph λKv. An NQS is said to be perfect if the inside K3, generated by the vertices x1, x4, x7, forms a S...

Neural quantum states (NQS) are a novel class of variational many-body wave functions that very flexible in approximating diverse states. Optimization an NQS ansatz requires sampling from the corresponding probability distribution defined by squared function amplitude. For this purpose we propose to use kinetic protocols and demonstrate many important cases such methods lead much smaller autoco...