نتایج جستجو برای: novel gold iii compound
تعداد نتایج: 1221757 فیلتر نتایج به سال:
It is evident that the chemistry of platinum is in a more advanced state than that of gold, mainly due to the success of the former in several anti-cancer drugs. With a view to finding possible, new candidates with chemotherapeutic potential, the use of sulphur-donor ligands bonded to platinum and gold is discussed herein in an attempt to promote the need to investigate similar ligands. Chloro(...
In an effort to discover potential alternatives to the anti-cancer drug cisplatin, the synthesis of gold(III) polypyridyl coordination complexes was pursued. Specifically, this report describes the synthesis and characterization of a series of 2,9-dialkyl-1,10-phenanthroline (Rphen) gold(III) coordination complexes (R = n-butyl, sec-butyl, and tert-butyl). Due to the steric hindrance imparted b...
We demonstrate a novel noncovalent method for producing Gd(III)-functionalized gold nanorods as multimodal contrast agents for MRI and CT imaging. The ligand is connected to the surface of the gold nanorods by a noncovalent bond making the Gd(III) ions directly accessible to water molecules, and resulting in a longitudinal relaxivity as high as 21.3 mM(-1) s(-1). In addition, compared with sphe...
We synthesized, characterized and tested in a panel of cancer cell lines, nine new bipyridine gold(III) dithiocarbamate-containing complexes. In vitro studies demonstrated that compounds 1, 2, 4, 5, 7 and 8 were the most cytotoxic in prostate, breast, ovarian cancer cell lines and in Hodgkin lymphoma cells with IC50 values lower than the reference drug cisplatin. The most active compound 1 was ...
Plasma membrane calcium ATPases (PMCA) are key proteins in the maintenance of (Ca2+) homeostasis. Dysregulation PMCA function is associated with several human pathologies, including neurodegenerative diseases, and, therefore, these potential drug targets to counteract those diseases. Gold compounds, namely Au(I), well-known for their therapeutic use rheumatoid arthritis and other diseases centu...
abstract compound is a word-formation process that are made two free morpheme (independent) and forms a new word with a new meaning that consists of meaning of both two component of compound. avestan language is one of the ancient iranian languages that is one of the indo-iranian languages. indo-iranian languages is one branch of indo-european languages. structure of compound noun and adjectiv...
Traditionally, compound splitters are evaluated intrinsically on gold-standard data or extrinsically on the task of statistical machine translation. We explore a novel way for the extrinsic evaluation of compound splitters, namely recognizing textual entailment. Compound splitting has great potential for this novel task that is both transparent and well-defined. Moreover, we show that it addres...
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