BACKGROUND /aims: In normal tension glaucoma (NTG) factors other than raised intraocular pressure have a role in the pathogenesis of the optic neuropathy. Because particular apolipoprotein E (ApoE) gene polymorphisms have been associated with cell death and survival in neurological degenerative diseases, the purpose of this study was to determine the ApoE allele frequencies in patients with nor...

Normal tension glaucoma (NTG) is a progressive optic neuropathy that mimics primary open-angle glaucoma, but lacks the findings of elevated intraocular pressure or other mitigating factors that can lead to optic neuropathy. The present review summarized the causes, genetics, and mechanisms underlying NTG in both animal models and human patients. We also proposed that the neurovascular unit is a...

Normal tension glaucoma (NTG) is a progressive optic neuropathy that mimics primary open-angle glaucoma, but lacks the findings of elevated intraocular pressure or other mitigating factors that can lead to optic neuropathy. The present review summarized the causes, genetics, and mechanisms underlying NTG in both animal models and human patients. We also proposed that the neurovascular unit is a...

Purpose: We compared visual field progression among patients with primary open-angle glaucoma (POAG), normal tension (NTG), and angle-closure (PACG).Methods: A total of 115 POAG, 123 NTG, 92 PACG eyes were retrospectively analyzed. Global VF was evaluated by calculating the changes mean deviations. To examine local deterioration, scotoma enlargement deepening analyzed in superior, inferior arcu...

Normal tension glaucoma (NTG) is labelled when typical glaucomatous disc changes, visual field defects and open anterior chamber angles are associated with intraocular pressure (IOP) constantly below 21 mmHg. Chronic low vascular perfusion, Raynaud's phenomenon, migraine, nocturnal systemic hypotension and over-treated systemic hypertension are the main causes of normal tension glaucoma. Goldma...

Normal tension glaucoma (NTG) also known as low tension glaucoma, presents with optic nerve head and visual field damage in the absence of high intraocular pressure (<21 mmHg). There are several patients of NTG seen in our clinics who have repeatable visual field defects, which may or may not correlate with the disc appearance, but are labeled as glaucoma. Ruling out ischemic, nutritional, and ...

BACKGROUND This study addresses the prevalence and clinical presentation of patients with primary open angle glaucoma (POAG) in the greater Accra metropolitan area. METHODS This is a retrospective case series of 455 patients (813 eyes) at the Emmanuel Eye Clinic. Patients were diagnosed from May 2008 to Nov 2011. The definition of POAG conformed to the International Society of Geographical an...

BACKGROUND Normal-tension glaucoma is a chronic progressive optic neuropathy of unknown etiology. Neuro-imaging workup in these patients is controversial. OBJECTIVES To determine the value of routine neurologic and neuro-ophthalmologic evaluations in patients with NTG. METHODS We conducted a retrospective review of all patients diagnosed with NTG in our institution between 2001 and 2006. Ne...

PURPOSE To evaluate the relationship between optic disc and retinal nerve fiber layer (RNFL) measurements obtained with the optical coherence tomography (OCT) and the Heidelberg retina topography (HRT) in normal, normal tension glaucoma (NTG), and high tension glaucoma (HTG). METHODS Normal, NTG and HTG subjects who met inclusion and exclusion criteria were evaluated retrospectively. One hund...

PURPOSE To determine if nerve fiber layer thickness (NFLT) in glaucoma patients decreases before the development of visual field loss, and if there is a difference in the thinning of NFLT between primary open-angle glaucoma (POAG) and normal-tension glaucoma (NTG) eyes. METHODS Thirty patients (33 eyes) with POAG and 31 patients (31eyes) with NTG, who had visual field defects localized in eit...