INTRA-ocuLAR pressure varies from individual to individual, from right eye to left eye, and from time to time. Many manometric studies have been made on experimental animals but observations on human eyes have been few: Wessely (1915, 1916) found an average of 22 5 and 18X5 mm. Hg, and Seidel (1922) one of 20 and 25 5 mm. Hg. Tonometric studies of human eyes, however, have been many; the result...

Normal pressure hydrocephalus (NPH) is a reversible disorder characterized by gait impairment, subcortical dementia, and urinary urgency and incontinence associated with impaired cerebrospinal fluid circulation and ventriculomegaly. Treatment with shunt surgery is most likely to increase mobility, and may also improve dementia and urinary symptoms. An international, independent study group rece...

Results: Forty-one patients underwent an invasive diagnostic procedure for evaluation of suspected NPH; 13 ultimately received shunts, representing an incidence of 1.19/100,000/year. The incidence of sustained definite improvements at 3 years after shunting was only 0.36/ 100,000/year. Definite gait improvement was documented in 75% at 3–6 months after shunt placement, although it dropped to 50...

The log-normal distribution is one of the most common distributions used for modeling skewed and positive data. In recent years, various methods for comparing the means of two independent log-normal distributions have been developed. In this paper a higher-order likelihoodbased method is proposed. The method is applied to two real-life examples and simulation studies are used compare the accura...

Idiopathic normal pressure hydrocephalus (iNPH) is a potentially reversible neurodegenerative disease commonly characterized by a triad of dementia, gait, and urinary disturbance. Advancements in diagnosis and treatment have aided in properly identifying and improving symptoms in patients. However, a large proportion of iNPH patients remain either undiagnosed or misdiagnosed. Using PubMed searc...