BACKGROUND Cancers are some of the leading causes of human deaths worldwide and their relative importance continues to increase. Since an increasing proportion of cancer patients are acquiring resistance to traditional chemotherapeutic agents, it is necessary to search for new compounds that provide suitable specific antiproliferative affects that can be developed as anticancer agents. Propolis...

      The present study was carried out to determine the hypoglycemic activity of the methanolic extract and solvent fractions (n-hexane and ethyl acetate) of Ruellia tuberosa in normal and alloxan-induced diabetic rabbits. Optimum dose of R. tuberosa for hypoglycemic activity was determined by oral administration of the methanolic extract (ME) to normal and diabetic ...

BACKGROUND Hyperglycemia, a characteristic feature of diabetes, induces glucotoxicity in pancreatic β-cells, resulting in further impairment of insulin secretion and worsening glycemic control. Thus, preservation of insulin secretory capacity is essential for the management of type 2 diabetes. In this study, we evaluated the ability of an Orthosiphon stamineus (OS) extract to prevent glucotoxic...

Polyhedral oligomeric silsesquioxanes (POSS) are multifunctional molecules that can be employed as building blocks to develop nanocomposite materials whose mechanical properties often improve upon those of traditional polymeric materials. We report here molecular simulation results for the effective potential of mean force between octamethyl POSS monomers and between POSS monomers in which one ...

Article history: Received on: 09/06/2014 Revised on: 17/07/2014 Accepted on: 04/08/2014 Available online: 27/08/2014 The present study was attempted to evaluate diuretic potency of total alcoholic extracts and its polar and non polar fractions of Priyala fruits (Buchanania angustifolia, Buchanania lanzan Fam: Anacardiaceae) in rats. Healthy adult Wistar albino rats weighing about 150-200 g were...

A simple and sensitive method for the simultaneous determination of ethanol, ethyl acetate, tetrahydrofuran, 2-propanol, hexane, dichloromethane and methanol in five drug substances by headspace techniques with FID detection is described. The method was validated for repeatability, linearity, limit of detection, limit of quantification and recovery according to the International Conference on H...

In the title compound, C18H23NO3, the cyclo-hexane ring has a chair conformation. The oxirane plane (OCC) makes a dihedral angle of 76.15 (13)° with that of the pyrrolidine ring to which it is fused. The mean plane of the cyclo-hexane ring and the benzene ring are almost normal to the pyrrolidine ring, with dihedral angles of 88.47 (8) and 77.85 (8)°, respectively. In the crystal, mol-ecules ar...