helicobacter pylori (h.pylori) is an etiologic factor for chronic gastritis and peptic ulcers. serological testing of h.pylori infection is common in iran, as other parts of the world. there are geographical variations in the humoral immune response to various h. pylori strains in different parts of the worl. we studied the immunogenic proteins of h.pylori by means of an immunoblot assay with a...

BACKGROUND Although many studies have found an association between Helicobacter pylori infection and the development of gastric cancer, many aspects of this relation remain uncertain. METHODS We prospectively studied 1526 Japanese patients who had duodenal ulcers, gastric ulcers, gastric hyperplasia, or nonulcer dyspepsia at the time of enrollment; 1246 had H. pylori infection and 280 did not...

of patient presentations at gastrointestinal clinics, and up to 50% or more of patients presenting with abdominal symptoms have no organic abnormality detected. The most common functional gastrointestinal conditions in Canada are irritable bowel syndrome (IBS), and functional dyspepsia or nonulcer dyspepsia (NUD). Other functional disorders may affect specific regions of the alimentary tract, s...

BACKGROUND The role of endoscopic biopsies in the detection of Helicobacter pylori in patients with nonulcer dyspepsia is poorly defined. This study assesses the cost-effectiveness of performing routine biopsies for the detection of H pylori at upper endoscopy in these patients. METHODS Clinical decision-making was modeled based on outcomes data from published articles and expert opinion. The...

The role of fibreoptic upper gastrointestinal endoscopy as the primary investigation in Malaysians presenting with dyspepsia was studied in 1119 patients. Five hundred and sixty-two of the examinations (50 percent) were normal. Females below 40 years of age were very likely to have normal endoscopies. Peptic ulcer was seen in 21 percent of patients while visual evidence of gastric or duodenal m...

The vacA s and m genotypes and the presence of cagA and IS605 were determined in Helicobacter pylori strains from patients with mono- and multiple infections. Surprisingly, these genetic markers were not associated with nonulcer dyspepsia or mucosa-associated lymphoid tissue lymphoma. The presence of cagA correlated with the presence of the vacA s1 allele (P < 0.05), whereas the presence of IS6...

BACKGROUND/AIM Management of dyspepsia may differ between countries. In Japan, Helicobacter pylori infection should be considered because of the high prevalence of the infection and the related diseases. I tried to propose an algorithm for stepwise diagnosis and treatment from uninvestigated dyspepsia to functional dyspepsia in clinical practice in Japan. METHODS A proposal was made from my p...