نتایج جستجو برای: nonstructural safety
تعداد نتایج: 266163 فیلتر نتایج به سال:
Glecaprevir (nonstructural protein 3/4A protease inhibitor) and pibrentasvir (nonstructural protein 5A inhibitor) (G/P), a coformulated once-daily, all oral, ribavirin (RBV)-free, direct-acting antiviral regimen, was evaluated for safety and efficacy in hepatitis C virus genotype 2 (GT2)-infected Japanese patients, including those with compensated cirrhosis. CERTAIN-2 is a phase 3, open-label, ...
Most control techniques in the structural engineering literature are aimed at improving performance of the primary structural part, but they may have limited or reverse effect on the nonstructural component during strong seismic events. In this paper, we emphasize the nonstructural performance using a cubic nonlinear active control system optimized in the frequency response functions of an SDOF...
INTRODUCTION A devastating earthquake is inevitable in the long term and likely in the near future in Iran. The objective of the study was to assess the knowledge of hospital staff to disaster management system in hospital and to determine nonstructural safety assessment in Shahid Mohammadi hospital in Bandar Abbas city of Iran. This hospital is the main referral hospital in Hormozgan province ...
background: the safety of rehabilitation centers is of great importance to ensure the well-being of patients. the present study aimed to determine non-structural and functional vulnerability of state rehabilitation centers of tehran city welfare organization in disasters using national standard instruments in 2014. materials and methods: this study has a descriptive and cross-sectional design. ...
The hepatitis C virus (HCV) encodes a large polyprotein; therefore, all viral proteins are produced in equimolar amounts regardless of their function. The aim of our study was to determine the ratio of nonstructural proteins to RNA that is required for HCV RNA replication. We analyzed Huh-7 cells harboring full-length HCV genomes or subgenomic replicons and found in all cases a >1,000-fold exce...
In order to increase our understanding of the assembly of the capsid proteins of AHSV, for the development of subunit vaccines and to study viral morphogenesis, it is necessary to investigate the interaction of the four major structural proteins of AHSV in the absence of other AHSV proteins and the viral genome. To investigate particle formation it was necessary to synthesise the proteins of in...
The Sindbis-group alphavirus S.A.AR86 encodes a threonine at nonstructural protein 1 (nsP1) 538 that is associated with neurovirulence in adult mice. Mutation of the nsP1 538 Thr to the consensus Ile found in nonneurovirulent Sindbis-group alphaviruses attenuates S.A.AR86 for adult mouse neurovirulence, while introduction of Thr at position 538 in a nonneurovirulent Sindbis virus background con...
Sindbis virus and Ross River virus are alphaviruses whose nonstructural proteins share 64% identity and whose structural proteins share 48% identity. Starting from full-length cDNA clones of both viruses, we have generated two reciprocal Sindbis-Ross River chimeric viruses in which the structural and nonstructural regions have been exchanged. These chimeric viruses replicate readily in several ...
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Plasmids were constructed which contained a large portion of each of the four nonstructural genes of Sindbis virus fused to the N-terminal two-thirds of the trpE gene of Escherichia coli. The large quantity of fusion protein induced from cells containing these plasmids was subsequently used as an antigen to generate polyclonal antisera in rabbits. Each antiserum was specific for the correspondi...
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