Immunoglobulin E has been associated with severe malaria suggesting a regulatory role for interleukin (IL)-4 and/or IgE in the pathogenesis of severe malaria. We have investigated possible associations between polymorphisms in the IL-4 repeat region (intron 3) and promoter regions (IL-4 +33CT and - 590CT) in Ghanaian children with severe malaria. There was a significantly higher frequency of IL...

Plasmodium infection (mainly p. falciparum) is usually complicated by cerebral malaria, haemolysis, acute kidney injury and respiratory distress. Myocardial involvement is a rare complication of plasmodium infection. We have reported a case of plasmodium infection (p. vivax) complicated by myocarditis.

Introduction: Malaria is among the most significant travel-related infections encountered by travelers to endemic countries in terms of morbidity and mortality. In Qatar, imported malaria has increased over the last 5 years; 493 travel-related cases were confirmed in 2016. In the current study, the knowledge of malaria chemoprophylaxis among physicians in the State of Qatar was...

Receptors encoded within the Natural Killer Cell (NKC) complex and Killer Immunoglobulin like (KIRs) genomic regions have been suggested to influence malaria pathogenesis and infection susceptibility. We have examined KIR locus in relation to risk of infection and disease in Tea tribes (TT) of Austro Asiatic affinity and Tibeto-Burman (TB) populations from malaria endemic regions of Assam. Cons...

Millions of people die from the parasitic disease malaria each year. This illness is difficult to diagnose in a clinical environment and arises when red blood cells are harmed. Malaria caused by Plasmodium parasites, which main global cause mortality morbidity. Both their hosts, vertebrates, carriers, mosquitoes, these parasites have complicated life cycle.

BACKGROUND Complicated malaria remains an important public health problem, particularly in endemic settings where access to health services is limited and consequently malaria fatal outcomes occur. Few publications describing the clinical course and outcomes of complicated malaria in Latin America are found in the literature. This prospective study approached the clinical and laboratory charact...

BACKGROUND Artemisinin-based combination therapy (ACT) has become the standard of care for the treatment of uncomplicated Plasmodium falciparum malaria. Although several ACT regimens are approved, data guiding optimal choices of ACTs are limited. We compared short- and long-term outcomes in a cohort of young Ugandan children randomized to 2 leading ACTs. METHODS Overall, 312 children were ran...

A record based study was conducted in a tertiary care centre of Odisha to know the socio-demographic and other epidemiological factors associated with the case fatality among the inpatient malaria cases admitted to medicine indoor. Total 557 laboratory confirmed malaria cases were studied. Majority of them (36%) belonged to 21-30 years age group and 85% were males. About 87% cases were from rur...

Multiple mechanisms such as genetic and epigenetic variations within a key gene may play a role in malarial susceptibility and response to anti-malarial drugs in the population. ABCB1 is one of the well-studied membrane transporter genes that code for the P-glycoprotein (an efflux protein) and whose effect on malaria disease predisposition and susceptibility to drugs remains to be understood. W...