The existence of neural opioid-mediated networks that are specific for the modulation of nociception is well established. Parallel non-opioid pathways exist, but their underlying physiology is little known. We now report that oxytocin administered intraperitoneally to rats, and intraperitoneally or intracisternally to mice has an anti-nociceptive effect, which is related to the activation of de...

BACKGROUND Although a number of clinical and preclinical studies have demonstrated analgesic effects of cannabinoid treatments, there are also instances when cannabinoids have had no effect or even exacerbated pain. The observed pro-nociceptive effects appear to be due to cannabinoid-induced disinhibition of afferent synaptic input to nociceptive circuits. To better understand how cannabinoid-m...

KEY POINTS Sleep spindle are usually considered to play a major role in inhibiting sensory inputs. Using nociceptive stimuli in humans, we tested the effect of spindles on behavioural, autonomic and cortical responses in two experiments using surface and intracerebral electroencephalographic recordings. We found that sleep spindles do not prevent arousal reactions to nociceptive stimuli and tha...

introduction: we investigated the role of atp-sensitive potassium channels and l-type calcium channels in morphine-induced hyperalgesia after nociceptive sensitization. methods: we used a hotplate apparatus to assess pain behavior in male nmri mice. nociceptive sensitization was induced by three days injection of morphine and five days of drug free. on day 9 of the schedule, pain behavior test ...

Study design: Case reports. Setting: University hospital setting. Objective: To analyze the effect of intravenous immunoglobulin on neuropathic and nociceptive pain in three patients with PostPolio Syndrome (PPS). Materials and Methods: Three patients with PPS and pain who received treatment with 90 g IvIg are described. Results: Before treatment one of the patients had pure neuropathic pain an...

introduction: it is known that acute and chronic stress induce hormonal and neuronal changes which affecting both pain threshold and nociceptive behaviours. orexin plays an important role in modulation of pain and stress. considering pain modulation during stress and the role of orexin in pain and stress, orexin might be involved in pain modulation during stress.we evaluated the involvement of ...

Introduction: Formalin injection induces nociceptive bahaviour in phase I and II, with a quiescent phase between them. While active inhibitory mechanisms are proposed to be responsible for initiation of interphase, the exact mechanisms which lead to termination of nociceptive response in phase II are not clear yet. Phase II is a consequence of peripheral and central sensitization processes, whi...

Background: Pre-operative nociceptive thresholds are able to predict patients susceptible to developing post-operative chronic pain. Thresholds are dependent on stimulus properties (i.e. pulsewidth (PW), number of pulses (NoP), and inter-pulse interval (IPI)) and are related to different mechanisms in the nociceptive system. Measuring multiple thresholds enables a detailed observation of periph...

The aim of this study, evaluate the nociceptive effect adalimumab, a TNF-alpha inhibitor, on formalin-induced inflammatory pain in mice. antinociceptive activity adalimumab was determined adult male BALB-C mice (6 each group) by model and hot plate test applied. Diclofenac, which we used as positive control, showed anti-nociceptive both phases formalin test. at thirtieth minute statistically si...

conclusions our findings suggest that the analgesic effect of hrcle may be mediated via both peripheral and central mechanisms. the presence of flavonoids might be responsible for the anti-nociceptive activity of this plant. results hrcle significantly inhibited the number of contractions induced by acetic acid in the writhing test at all doses, while anti-nociceptive activity was only shown at ...