microglia, the sentries of the brain, is highly implicated in neurodegeneration as in neuroprotection. chronic microglial activation endangers neuronal survival through the release of various potentially neurotoxic mediators including nitric oxide (no). thus, negative regulators of microglial activation have been considered as potential therapeutic candidates to target neurodegeneration, such a...

A potential of about -0.8 (+/-0.2) V (at 1 M versus normal hydrogen electrode) for the reduction of nitric oxide (NO) to its one-electron reduced species, nitroxyl anion (3NO-) has been determined by a combination of quantum mechanical calculations, cyclic voltammetry measurements, and chemical reduction experiments. This value is in accord with some, but not the most commonly accepted, previou...

We recently reported that nitric oxide (NO) induces posttranscriptional modulation of lung endothelial cell NO synthase (ecNOS) that results in loss of activity. The loss of activity can be reversed by the redox regulatory proteins thioredoxin (Thx)/thioredoxin reductase (Thx-R). The present study was designed to examine whether diminished expression of endogenous Thx and Thx-R may account for ...

The mechanism of the electrochemical reduction of nitric oxide (NO) by hemin adsorbed at pyrolitic graphite was investigated. The selectivity of NO reduction was probed by combining the rotating ring disk electrode (RRDE) technique with a newly developed technique called on-line electrochemical mass spectroscopy (OLEMS). These techniques show that NO reduction by adsorbed heme groups results in...

This paper deals with the effectiveness of several alternative models of aid allocation in terms of poverty reduction. We use a model that admits the presence of diminishing returns to aid in the output and poverty functions. We shall discuss the impact of aid on poverty in a single country, showing that conditional aid to improve policies has a deeper impact than the other alternatives of aid ...

In a previous article, White et al 1 concluded that the horizontal breast reduction technique yields superior breast scars. The authors claimed that theirs was the first prospective study to evaluate breast reduction scars. However, other published studies, both prospective and retrospective , have compared vertical and inverted-T scars, finding that patients prefer a vertical scar. One study, ...

Pyocyanin (PCN), a virulence factor synthesized by Pseudomonas aeruginosa, plays an important role during clinical infections. There is no study of the effect of nitric oxide (NO) on PCN biosynthesis. Here, the effect of NO on PCN levels in Pseudomonas aeruginosa strain PAO1, a common reference strain, was tested. The results showed that the NO donor sodium nitroprusside (SNP) can significantly...