نتایج جستجو برای: nnos

تعداد نتایج: 2006  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1997
Y A Kolesnikov Y X Pan A M Babey S Jain R Wilson G W Pasternak

Several isoforms of neuronal nitric oxide synthase (nNOS) have been identified. Antisense approaches have been developed which can selectively down-regulate nNOS-1, which corresponds to the full-length nNOS originally cloned from the brain, and nNOS-2, a truncated form lacking two exons which is generated by alternative splicing, as demonstrated by decreases in mRNA levels. Antisense treatment ...

Journal: :Health Sciences 2023

Nepavykusios nugaros operacijos sindromui (NNOS) būdingas nuolatinis ir (arba) pasikartojantis apatinės nu­garos dalies skausmas, kuris išlieka nepaisant chirurginės intervencijos arba atsiranda po dėl stuburo skausmo. Operacija gali sustiprinti nepakankamai palengvinti esamą skausmą. Moterims NNOS pasireiškia dažniau nei vyrams, o ligos paplitimas didėja su amžiumi. Tyrimo tikslas – apžvelgti ...

Journal: :American journal of physiology. Renal physiology 2010
Deyin Lu Yiling Fu Arnaldo Lopez-Ruiz Rui Zhang Ramiro Juncos Haifeng Liu R Davis Manning Luis A Juncos Ruisheng Liu

Neuronal nitric oxide synthase (nNOS), which is abundantly expressed in the macula densa cells, attenuates tubuloglomerular feedback (TGF). We hypothesize that splice variants of nNOS are expressed in the macula densa, and nNOS-beta is a salt-sensitive isoform that modulates TGF. Sprague-Dawley rats received a low-, normal-, or high-salt diet for 10 days and levels of the nNOS-alpha, nNOS-beta,...

Journal: :Brain research 2005
Satoru Sato Claudean S Braham Susan K Putnam Elaine M Hull

Neuronal nitric oxide synthase (nNOS) in the medial preoptic area (MPOA) has been implicated in various physiological functions, including male rat copulation. Based on their apparent sensitivity to gonadal steroid manipulation, we hypothesized that nNOS cells contain steroid receptors, and the testosterone-induced restoration of nNOS-immunoreactivity in castrates should accompany the restorati...

Mohammad Mohammadzadeh, Sajad Sahab Negah, Zinat Heidarnia,

Neuronal nitric oxide synthase (nNOS) plays a role in synaptic potentiation and kindling process.The relationship between nNOS and 5-HT1A receptors also nearly has been specified. In this research,we investigate the role of nNOS on the anticonvulsant effect of 5-HT1A receptors. 24 male (280 ± 30 g) were randomly assigned to four groups (vehicle,NI,Way 100635 and NI + Way100635) (n = 6). ...

Journal: :Neuron 1998
Samie R Jaffrey Adele M Snowman Mikael J.L Eliasson Noam A Cohen Solomon H Snyder

Nitric oxide (NO) produced by neuronal nitric oxide synthase (nNOS) is important for N-methyl-D-aspartate (NMDA) receptor-dependent neurotransmitter release, neurotoxicity, and cyclic GMP elevations. The coupling of NMDA receptor-mediated calcium influx and nNOS activation is postulated to be due to a physical coupling of the receptor and the enzyme by an intermediary adaptor protein, PSD95, th...

Journal: :Circulation 2009
Dylan E Burger Xiangru Lu Ming Lei Fu-Li Xiang Lamis Hammoud Mao Jiang Hao Wang Douglas L Jones Stephen M Sims Qingping Feng

BACKGROUND Neuronal nitric oxide synthase (nNOS) is expressed in cardiomyocytes and plays a role in regulating cardiac function and Ca2+ homeostasis. However, the role of nNOS in cardiac electrophysiology after myocardial infarction (MI) is unclear. We hypothesized that nNOS deficiency increases ventricular arrhythmia and mortality after MI. METHODS AND RESULTS MI was induced in wild-type (WT...

Journal: :Circulation research 2003
Claire E Sears Simon M Bryant Euan A Ashley Craig A Lygate Stevan Rakovic Helen L Wallis Stefan Neubauer Derek A Terrar B Casadei

A neuronal isoform of nitric oxide synthase (nNOS) has recently been located to the cardiac sarcoplasmic reticulum (SR). Subcellular localization of a constitutive NOS in the proximity of an activating source of Ca2+ suggests that cardiac nNOS-derived NO may regulate contraction by exerting a highly specific and localized action on ion channels/transporters involved in Ca2+ cycling. To test thi...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2000
M Sasaki M Gonzalez-Zulueta H Huang W J Herring S Ahn D D Ginty V L Dawson T M Dawson

Neuronal nitric oxide (NO) synthase (nNOS) is dynamically regulated in response to a variety of physiologic and pathologic stimuli. Although the dynamic regulation of nNOS is well established, the molecular mechanisms by which such diverse stimuli regulate nNOS expression have not yet been identified. We describe experiments demonstrating that Ca(2+) entry through voltage-sensitive Ca(2+) chann...

Journal: :Experimental and therapeutic medicine 2017
Zhibo Ding Xingjie Shen Yunfei Li

The present study aimed to investigate the changes of Rho-associated kinase (Rho-kinase) and neuronal nitric oxide synthase (nNOS) expression in age-associated erectile dysfunction (ED) in Sprague-Dawley (SD) rats. A total of 100 intact male SD rats were divided into 20 groups according to their age (5-24 months; rats that were the same age in months were in the same group). Erectile response m...

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