Androgen receptor (AR) splice variants (ARVs) are implicated in development of castration-resistant prostate cancer (CRPC). Upregulation of ARVs often correlates with persistent AR activity after androgen deprivation therapy (ADT). However, the genomic and epigenomic characteristics of ARV-dependent cistrome and the disease relevance of ARV-mediated transcriptome remain elusive. Through integra...

Desferrioxamine (DFO) and the hydroxypiridinone (HPO) deferiprone (CP20) chelate iron as well as other metals. These chelators are used clinically to treat iron overload, but they induce apoptosis in thymocytes. Thymocyte apoptosis is potentiated by zinc deficiency, suggesting that these iron chelators may induce apoptosis by depleting stores of zinc. Exposure of murine thymocytes to either DFO...

It is suggested that the observed excess of muons in studies of pp̄ collisions at √ s = 1.96 TeV arises from the decay of doubly-charged bosons. Such particles are predicted in the 3-3-1 model where the electroweak gauge group is extended to SU(3)× U(1). ∗[email protected]

Desferrioxamine (DFO) and the hydroxypiridinone (HPO) deferiprone (CP20) chelate iron as well as other metals. These chelators are used clinically to treat iron overload, but they induce apoptosis in thymocytes. Thymocyte apoptosis is potentiated by zinc deficiency, suggesting that these iron chelators may induce apoptosis by depleting stores of zinc. Exposure of murine thymocytes to either DFO...

Cyclic polyamine 1,4,7-trimethyl-1,4,7,10-tetraazacyclododecane, (Me(3)TACD)H (= Me(3)[12]aneN(4)), reacted with [K{N(SiHMe(2))(2)}] in benzene-d(6) to give [K{(Me(3)TACD)SiMe(2)N(SiHMe(2))}] (1) under hydrogen evolution. Single-crystal X-ray diffraction of 1 shows a dinuclear structure in the solid state, featuring a bridging μ-amido and a weak β-agostic Si-H bond. 1,7-Dimethyl-1,4,7,10-tetraa...

BACKGROUND In Japan, breast-conserving surgery with closed cavity has generally been performed for breast cancer patients, and accelerated partial breast irradiation (APBI) is considered difficult because Asian females generally have smaller breast sizes than Western females. Therefore, common identification of target and treatment plan method in APBI is required. A prospective multicenter stud...

A number of Internet application protocols have a need to provide content negotiation for the resources with which they interact [1]. A framework for such negotiation is described in [2], part of which is a way to describe the range of media features which can be handled by the sender, recipient or document transmission format of a message. A format for a vocabulary of individual media features...

A number of Internet application protocols have a need to provide content negotiation for the resources with which they interact [1]. A framework for such negotiation is described in [2], part of which is a way to describe the range of media features which can be handled by the sender, recipient or document transmission format of a message. A format for a vocabulary of individual media features...

Domain-Specific Languages (DSLs) are now developed for a wide variety of domains to address specific concerns in the development of complex systems. However, DSLs and their tooling still suffer from substantial development costs which hamper their successful adoption in the industry. For over a decade, researchers and practitioners have developed language workbenches with the promise to ease th...