نتایج جستجو برای: nk1r

تعداد نتایج: 208  

Journal: :Journal of Investigative Dermatology 2023

The number of people suffering from symptoms sensitive skin has been growing. Their main pains are specified as dryness and chronic itch. Recent studies showed that Substance P (SP) Neurokinin 1 receptor (NK1R) on the C nerve fibers related to Focusing this pathway, we discovered maltotetraose (MTO), a type polysaccharide, alleviated itch skin. Single-center, open-label clinical trials formulat...

2016
Katharine Pillidge David J Heal S Clare Stanford

The abnormal behaviour of NK1R-/- mice (locomotor hyperactivity, inattentiveness and impulsivity in the 5-Choice Serial Reaction-Time Test) is arguably analogous to that of patients with attention deficit hyperactivity disorder (ADHD). Evidence suggests that small body size and increased body weight are risk factors for ADHD. Here, we compared the body size, body mass and body composition of ma...

Journal: :The international journal of neuropsychopharmacology 2007
Mikko J Nyman Olli Eskola Jaana Kajander Tero Vahlberg Sandra Sanabria Donald Burns Richard Hargreaves Olof Solin Jarmo Hietala

Substance P (SP) is a neurotransmitter and neuromodulator that mediates its effects in the brain predominantly via the neurokinin-1 receptors (NK1Rs). NK1Rs and SP have been shown clinically to be involved in nausea and emesis after chemotherapy (CINV) and have been implicated preclinically in a range of neuropsychiatric disorders but unlike CINV their blockade in these conditions does not have...

2009
K.S. Al Ghamdi E. Polgár A.J. Todd

Lamina I of the spinal dorsal horn contains neurons that project to various brain regions, and approximately 80% of these projection cells express the neurokinin 1 receptor (NK1r), the main receptor for substance P. Two populations of NK1r-immunoreactive neurons have been identified in lamina I: small weakly immunoreactive cells and large cells with strong immunolabelling [Cheunsuang O and Morr...

Journal: :American journal of physiology. Lung cellular and molecular physiology 2008
J Xu F Xu E Barrett

Metalloelastase (MMP-12), mainly produced by macrophages, has been shown to play a key role in the pathogenesis of emphysema in animal models. Chronic cigarette smoke increases pulmonary MMP-12, which is closely correlated with an elevation of pulmonary substance P (SP). Because alveolar macrophages (AMs) contain the neurokinin-1 receptor (NK1R), we tested whether SP was able to trigger the upr...

2015
Ashley J. Porter Katharine Pillidge Ewelina M. Grabowska S. Clare Stanford

Mice lacking functional neurokinin-1 receptors (NK1R-/-) display behavioural abnormalities resembling attention deficit hyperactivity disorder (ADHD): locomotor hyperactivity, impulsivity and inattentiveness. The preferred ligand for NK1R, substance P, is metabolised by angiotensin converting enzyme (ACE), which forms part of the brain renin angiotensin system (BRAS). In view of evidence that t...

2010
TC Yan A McQuillin A Thapar P Asherson SP Hunt SC Stanford H Gurling

Mice with functional genetic ablation of the Tacr1 (substance P-preferring receptor) gene (NK1R-/-) are hyperactive. Here, we investigated whether this is mimicked by NK1R antagonism and whether dopaminergic transmission is disrupted in brain regions that govern motor performance. The locomotor activity of NK1R-/- and wild-type mice was compared after treatment with an NK1R antagonist and/or ps...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2002
Fabien Schmidlin Olivier Déry Nigel W Bunnett Eileen F Grady

Cells express multiple G protein-coupled receptors that are simultaneously or sequentially activated by agonists. The consequences of activating one receptor on signaling and trafficking of another receptor are unknown. We examined the effects of selective activation of the neurokinin 1 receptor (NK1R) on signaling and trafficking of the NK3R and vice versa. Selective agonists of NK1R and NK3R ...

2013
Ming-Ming Zhang Wei Ji Li-Yu Pei Wen Wang Tao Chen Wei Wang Hui Li Ting Zhang Sheng-Xi Wu Yun-Qing Li

Substance P (SP) and its receptor, the neurokinin 1 receptor (NK1R), play important roles in transmitting and regulating somatosensory nociceptive information. However, their roles in visceral nociceptive transmission and regulation remain to be elucidated. In the previous study, moderate SP immunoreactive (SP-ir) terminals and NK1R-ir neurons were observed in the dorsal commissural nucleus (DC...

Journal: :Journal of immunology 2005
Alexandra Svensson Joanna Kaim Carina Mallard Annika Olsson Ernst Brodin Tomas Hökfelt Kristina Eriksson

We show that genital infection with neurotropic HSV type 2 (HSV-2) induced a significant increase of the neuropeptide substance P (SP) within the genital tract of mice. SP was shown to weakly interfere with the HSV-2 replication. Furthermore, lack of SP signaling through the use of mice deficient in the SP receptor, neurokinin 1 receptor (NK1R), revealed an important role for SP in the innate d...

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