نتایج جستجو برای: nitric oxide donors
تعداد نتایج: 215521 فیلتر نتایج به سال:
Knowledge of phosphorylation events and their regulation is crucial to understanding the functional biology of plant proteins, but very little is currently known about nitric oxide-responsive phosphorylation in plants. Here, we report the first large-scale, quantitative phosphoproteome analysis of cotton (Gossypium hirsutum) treated with sodium nitroprusside (nitric oxide donor) by utilizing th...
The development of multidrug resistance (MDR) not only actively transports a wide range of cytotoxic drugs across drug transporters but is also a complex interaction between a number of important cellular signalling pathways. Nitric oxide donors appear to be a new class of anticancer therapeutics for satisfying all the above conditions. Previously, we reported furoxan-based nitric oxide-releasi...
Nitric oxide (NO)-release from polymer metal composites is achieved through the incorporation of NO donors such as S-nitrosothiols (RSNO). Several studies have shown that nanoparticles catalytically decompose RSNO to...
BACKGROUND Nitric oxide donors are widely used to treat cardiovascular disease, but their major limitation is the development of tolerance, a multifactorial process to which the in vivo release of nitric oxide is thought to contribute. Here we describe the preclinical and clinical results of a translational drug development effort to create a next-generation nitric oxide donor with improved pha...
BACKGROUND The main cause of reduced long-term graft survival is chronic allograft injury. Cardiovascular risk factors such as hyperhomocysteinaemia, accumulation of asymmetric dimethylarginine, increased oxidative stress and decreased production of nitric oxide seem to play an important role. Functional polymorphisms of the endothelial isoform of nitric oxide synthase (NOS) gene cause an alter...
The exogenous nitric oxide donor, sodium nitroprusside, evaluated the recombinogenic potential of nitric oxide. Drug inhibited mycelial growth and conidiation in A757 Aspergillus nidulans master strain. Two heterozygous diploid strains, one wild (uvsH//uvsH) and the other defective to DNA repair (uvsH//uvsH) were used for recombinagenesis tests. Sodium nitroprusside recombinogenic effect was ev...
Literature data concerning the role of endothelium and nitric oxide in pathogenesis cardiovascular diseases, administration L-arginine as a part comprehensive therapy patients suffering from essential hypertension (EH) ischemic heart disease (IHD) are cited.Objective: to systematize current literature clinical experience with EH IHD. Conclusion. Nowadays endothelial dysfunction conception is de...
Leppert, P.C. and Yu, S.Y. (1994) Apoptosis of cervical cells in pregnant rats occurs in association with cervical softening. Gynecol. Obstet. Invest., 37, 150-154. Liggins, G.C. (1981) Cervical ripening as an inflammatory reaction. In Ellwood, D.A. and Anderson, A.B.M. (eds), The Cervix in Pregnancy and Labour. Churchill Livingstone, Edinburgh, UK, pp. 1-9. Purcell, T.L., Buhmischi, I., Given,...
exogenous nitric oxide donors such as deta nonoate, spontaneously release nitric oxide. this study aimed to investigate the effect of deta nonoate as a nitric oxide releasing drug on the rate of collagen synthesis during the impaired wound healing in a rat model of diabetes. twelve male sprague–dawley rats were transferred into separate metabolic cages. nine days before wounding, the rats were ...
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