The aim of this work was to determine if the inhibition or stimulation of NO synthesis modulates liver damage induced by chronic lead intoxication. Lead nitrate (3.6 mg/kg, per os) was administered one time a day for 30 days to male Wistar rats with low and high resistance to hypoxia treated simultaneously with L-arginine (600 mg/kg, i.p.) or N-nitro-L-arginine (L-NNA, 35 mg/kg, i.p.) 30 min. b...

Most of the information which has been collected on salivary composition in different disease states (with the notable exception of that in digitalis intoxication) has proved of little practical diagnostic value. Diagnostic use of saliva has become more extensive in recent years, particularly in relation to estimation of systemic levels of lipid-soluble drugs and hormones. Thiocyanate levels ha...

background: acute appendicitis is the most common surgical emergency of the childhood. its diagnosis is really challenging. a constellation of through history taking, physical examination, radiographic investigations, and laboratory analysis should be used to balance the risk of delayed operative intervention against the removal of a normal appendix. here a case with misdiagnosis of acute appen...

bachground: paraquat (pq) intoxication manifests with pulmonary edema and fibrosis, heart failure, hepatic failure, and sometimes convulsions. in severe cases, the patients may die within the early hours. at best conditions, the conventional therapeutic methods can only save less than 50% of the victims of intentional pq intoxication. the aim of this study was to evaluate the outcome of new the...

stereologic methods are used to abtain quantitative information about 3-dimensional structures from histologic sections. the aim of the present study was using new and unbiased stereologic techniques to investigate changes in volume and number of glomeruli after chronic lead acetate intoxication both quantitatively and in 3-dimensional spaces.lead is one of the heavy metals that has adverse eff...

The in vivo protective role of hydro-methanolic root extract of Withania somnifera (WS) was evaluated in alleviating lead nitrate (LN)-induced toxicity in male Swiss albino mice by measuring hematoserological profiles. The lead-treated (20 mg/kg body wt, p.o.) albino mice (25-30 g) concurrently received the root extract (200 and 500 mg/kg body wt, p.o.) once daily for the duration of six weeks....

Forty seven of 150, 15-month-old long weaners died of an acute renal disease syndrome following introduction into an old maize field with a heavy stand of Amaranthus spp. The clinical syndrome was characterised by sudden onset neurological disease with ataxia and recumbency. Subcutaneous oedema, ascites and perirenal oedema with urine odour were the major gross necropsy findings. Renal histopat...