Effect of nicotinic acid on the formation of catecholamine has been studied. Norepinephrine and dopamine concentrations in brain were 30 per cent higher and brain catecholamine formation was 50 per cent higher in the nicotinic acid-supplemented rats than the nicotinic acid-deficient rats. However, these catecholamine levels of the nicotinic acid-deficient rats were recovered by the administrati...

Application o f [6 14C]or [7-14C]nicotinic acid to parsley cell suspension cultures led to the accumulation of labelled nicotinamide m ononucleotide, nicotinamide adenine dinucleotide, nicotinamide N-riboside, nicotinamide and nicotinic acid, indicating the operation of the pyridine nucleotide cycle in these cells. A s main conjugates, nicotinic acid N-glucoside and nicotinic acid glucose ester...

Several compounds have been described as metabolites of nicotinic acid and nicotinamide in mammals. These are nicotinic acid (I), nicotinamide (2)) nicotinuric acid (2)) trigonelline (2)) W-methylnicotinamide (NMN) (3-6)) and 1-methyl-3-carboxylamide-6-pyridone (7, 8). According to the observations of various workers mammals may be divided into two groups in so far as the metabolism of nicotini...

In 1946, Rosen e2 al. (1) showed that administration of tryptophan to rats resulted in an additional excretion of nicotinic acid and Nl-methylnicotinamide (Nl-Me). Singal et al. (2) found, in addition to these, increased excretion of another metabolite which could be converted to nicotinic acid by autoclaving in 1 N sulfuric acid solution. Henderson isolated this metabolite from the urine of ra...

Nicotinic acid and nicotinamide belong to the water-soluble vitamins, and they have many physiological and pharmacological functions in various organisms. In this study, we investigated the differentiation-inducing ability of nicotinic acid-related compounds in chronic myelogenous leukemia K562 cell line. Proliferation of K562 leukemia cells was inhibited by several nicotinic acid-related compo...

The metabolism of nicotinic acid and nicotinamide has been examined in a number of mouse tissues following intraperitoneal injection of 0.9 pmole of W-labeled nicotinic acid and nicotinamide. In all the tissues except liver, and to some extent intestine, nicotinamide was clearly a better precursor of DPN than was nicotinic acid. In the case of liver and intestine [14C]nicotinic acid produced a ...

The antidyslipidemic drug nicotinic acid (niacin) has been used for decades. One of the major problems of the therapeutical use of nicotinic acid is a strong cutaneous vasodilation called flushing, which develops in almost every patient taking nicotinic acid. Nicotinic acid-induced flushing has been shown to be mediated by the nicotinic acid receptor GPR109A and to involve the formation of vaso...

Background: Some health-protecting secondary metabolites can be found at a higher concentration in the sprouts compared to other stages of plant growth. In addition, environmental stresses such as salt stress may be resulting in the increase or decrease of specific secondary metabolites in sprouts and plants. Objective: Evaluation the changes of trigonelline, nicotinic acid, and proline cont...