alcoholic liver disease (ald) is the main cause of chronic liver disease across the world and can lead to fibrosis and cirrhosis. the etiopathogenesis of ald is related to ethanol-induced oxidative stress, glutathione reduction, abnormal methionine metabolism, malnutrition, and production of endotoxins that activate kupffer cells. curcumin is an active ingredient of the rhizome of turmeric. the...

Transcription factors bind specifically to their target elements in the genome, eliciting specific gene expression programs. The nuclear factor-?B (NF-?B) system is a family of proteins comprising inducible transcription activators, which play critical role inflammation and cancer. NF-?B members function as dimers with each monomeric unit binding ?B-DNA. Despite available structures various com...

a graph g is said to have a totally magic cordial labeling with constant c if there exists a mapping f : v (g) ∪ e(g) → {0, 1} such that f(a) + f(b) + f(ab) ≡ c (mod 2) for all ab ∈ e(g) and |nf (0) − nf (1)| ≤ 1, where nf (i) (i = 0, 1) is the sum of the number of vertices and edges with label i. in this paper, we give a necessary condition for an odd graph to be not totally magic cordial and ...

A graph G is said to have a totally magic cordial labeling with constant C if there exists a mapping f : V (G) ∪ E(G) → {0, 1} such that f(a) + f(b) + f(ab) ≡ C (mod 2) for all ab ∈ E(G) and |nf (0) − nf (1)| ≤ 1, where nf (i) (i = 0, 1) is the sum of the number of vertices and edges with label i. In this paper, we give a necessary condition for an odd graph to be not totally magic cordial and ...

Neuroinflammation contributes to delayed (secondary) neurodegeneration following traumatic brain injury (TBI). Tumor necrosis factor receptor-associated 6 (TRAF6) signaling may promote post-TBI neuroinflammation, thereby exacerbating secondary injury. This study investigated the pathogenic functions of TRAF6 TBI in vivo and vitro . A rat model was established by air pressure contusion while lip...

Myocardial infarction and cerebral ischemic stroke are prominent causes of death worldwide. Platelets play major roles in these diseases, although they anucleated cells, but also express the NF-?B. Pterostilbene (PTE) possesses some intriguing pharmacological properties, including capacity to inhibit platelet activation. We investigated inhibitory role PTE NF-?B-mediated signal events compared ...