PURPOSE Previous studies of connexin-related hearing loss have typically reported on mixed age groups or adults. To further address epidemiology and natural history of connexin-related hearing loss, we conducted a longitudinal study in an ethnically diverse cohort of infants and toddlers under 3 years of age. Our study compares infants with and without connexin-related hearing loss to examine d...

OBJECTIVE To identify intrapartum predictors of newborn encephalopathy in term infants. DESIGN Population based, unmatched case-control study. SETTING Metropolitan area of Western Australia, June 1993 to September 1995. SUBJECTS All 164 term infants with moderate or severe newborn encephalopathy; 400 randomly selected controls. MAIN OUTCOME MEASURES Adjusted odds ratio estimates. RESU...

Background & Aims: Hydronephrosis is a common problem in prenatal and newborn infants diagnosed by ultrasonography. Bladder to ureter reflux, the upper or lower urinary tract obstruction, and neurogenic bladder are the most common causes of hydronephrosis in newborns and infants. Methods: In this study, 100 neonates and infants with hydronephrosis were observed clinically and laboratorically fo...

OBJECTIVE To detail low molecular mass heparin (enoxaparin) use in the first few months of life. DESIGN Prospective, consecutive cohort of unselected newborn infants. METHODS Newborn infants were divided into groups by gestational age, underlying condition, hepatic and renal function, thrombocytopenia, and prothrombin time (PT/INR). Groups were analysed with respect to many aspects of enoxa...

background and aims: glucose-6-phosphate dehydrogenase (g6pd) is the first enzyme in the route of pentose phosphate metabolism. this route fulfills an effective role in removing oxidant metabolites. deficiency of this enzyme causes decline in energy regeneration of red blood cells and hemolysis. in this study, application of fluorescence staining method in diagnosing the frequency of g6pd defic...

OBJECTIVE To investigate whether the resistance index (RI) within the first 72 hours of life of newborn infants with cerebral white matter lesion (WML) is correlated with the adverse outcome of WML. METHODS Retrospective study. Newborn infants with WML were identified based on cranial ultrasound results, and those with Doppler imaging and RI measurement were selected. The newborn infants were...

Intraventricular haemorrhage may occur de novo in previously well, term newborn infants. In a group of six neonates a high incidence of posthaemorrhagic hydrocephalus was found. Posthaemorrhagic hydrocephalus may be more common in full term newborn infants than previously recognised.