a 25-year-old woman with a history of five years of bilateral verrucous hyperkeratosis and darkening of both nipples and areolae is reported herein. the histopathology was suggestive of hyperkeratosis of areola and nipple. hyperkeratosis of areola and nipple is a rare condition which is seen unilaterally or bilaterally in both sexes. three types of hyperkeratosis of areola and nipple are descri...

Mycosis fungoides is one of the great imitators in dermatology; it can mimic many dermatoses. Nevoid hyperkeratosis of the nipple and areola is a rare idiopathic disease with typical clinical features of verrucous thickening and brownish discoloration of the nipple, areola or both. Here, a 16-year-old male patient with mycosis fungoides mimicking nevoid hyperkeratosis of the nipple and areola h...

NHNA: nevoid hyperkeratosis of the nipple and/or areola INTRODUCTION Nevoid hyperkeratosis of the nipple and/or areola (NHNA) is an uncommon skin disease without welldefined etiology, reported for the first time in 1923. The disease is characterized by slowly growing verrucous thickening and brown pigmentation of the areola or nipple. Here we report a lesion on the nipple clinically and dermosc...

1. Veeranna S, Betkerur J, Kushalappa PA. Unilateral nevoid hyperkeratosis of the nipple: A report of two cases. Indian J Dermatol Venereol Leprol 2006;72:303-5. 2. Baykal C, Buyukbabani N, Kavak A, Alper M. Nevoid hyperkeratosis of the nipple and areola: A distinct entity. J Am Acad Dermatol 2002;46:414-8. 3. Revert A, Banuls J, Montesinos E, Jorda E, Ramon D, Torres V. Nevoid hyperkeratosis o...

INTRODUCTION Nevoid basal cell carcinoma syndrome, or Gorlin syndrome, is an inherited disorder characterized by malignancies of the skin and other organs, skeletal abnormalities, and congenital malformations. The syndrome follows an autosomal dominant inheritance pattern with a gene mutation localized to 9q22.3. CASE PRESENTATION We present the case of a 22-year-old Caucasian woman with a un...

Photodynamic therapy is an effective alternative for the treatment of non-melanoma skin cancer, selectively destroying the neoplastic cells through the use of photosensitizer substances that are irradiated with a source of light of adequate wave length. Nevoid Basal Cell Carcinoma Syndrome is a genodermatosis characterized by multiples basal cell carcinomas occurring at an early age, compelling...

Occurrence of multiple odontogenic keratocyst involving the jaws is rare. When multiple, it is usually associated with a syndrome. Occurrence of multiple odontogenic keratocyst without syndromic association is extremely rare. Gorlin-Goltz syndrome which is also known as Nevoid Basal Cell Carcinoma Syndrome is a rare autosomal dominant disorder. Multiple Odontogenic Keratocysts (OKCs) are princi...

We report the case of a 53-year-old Caucasian woman who developed nodal melanoma metastasis under infliximab therapy 2 years after the removal of a nevoid melanoma, which was initially misdiagnosed as a benign compound nevus. This case illustrates the potential link between tumor necrosis factor (TNF)-α inhibition and the reactivation of latent melanoma. Furthermore, this case highlights the ne...

Acathosis nigricans (AN) typically presents as symmetric, brownish-black, velvety, hypertrophic, verrucous, and at times papillomatous plaques most commonly involving the flexural sites [1]. It is a cutaneous marker, most frequently of insulin resistance and less frequently of malignancy [2]. AN has been classified into 8 types: benign, obesity-related, syndromic, malignant, unilateral, acral, ...