Heterozygous mutations in the NLRP3 gene in patients with cryopyrin associated periodic syndrome (CAPS) lead to hyper-responsive inflammasome function. CAPS is a systemic auto-inflammatory syndrome characterized by the activation of the innate immune system induced by elevated pro-inflammatory cytokines, but the involvement of selective innate immune cells in this process is not fully understoo...

Pro-inflammatory cytokine release (IL-8, IL-6, TNF-α, IL-1β) by peripheral blood neutrophils, isolated from periodontitis patients (before/after therapy) and matched controls, was determined after 18 h culture in the presence/absence of Escherichia coli LPS, opsonised Staphylococcus aureus, heat-killed Fusobacterium nucleatum and Porphyromonas gingivalis. All cultures demonstrated differences i...

in this note first we define the notions of fuzzy positive implicativehyper bck-ideals of types 1,2,3 and 4. then we prove some theorems whichcharacterize the above notions according to the level subsets. also we obtainthe relationships among these notions, fuzzy (strong, weak, reflexive) hyperbck-ideals and fuzzy positive implicative hyper bck-ideals of types 5,6,7and 8. then, we define the no...

The cis-[WO2F4] anion is inherently acentric and contains polarizable WdO bonds, making it a good candidate for second-harmonic generation (SHG). However, the orientational disorder commonly found in crystal structures containing [WO2F4] must be understood as a first step toward engineering a polar SHG material with this anion. The strategy of crystallizing the [WO2F4] anion with two different ...

Periodontal disease is a well-regulated response to bacterial infection directed by the inflammatory cells of the host immune system. The host response to injury or insult is implicated to be a vital feature of the majority of periodontal diseases. The excessive activation of neutrophils plays a role in the pathogenesis in diseases such as acute respiratory distress syndrome, rheumatoid arthrit...

in this paper, we aresupposed to introduce the definitions of n-fold commutative, andimplicative hyper k-ideals. these definitions are thegeneralizations of the definitions of commutative, andimplicative hyper k-ideals, respectively, which have been definedin [12]. then we obtain some related results. in particular wedetermine the relationships between n-fold implicative hyperk-ideal and n-fold...

BACKGROUND The virulence role of surface antigens in a single serotype of Klebsiella pneumoniae strain have been studied, but little is known about whether their contribution will vary with serotype. METHOD To investigate the role of K and O antigen in hyper-virulent strains, we constructed O and K antigen deficient mutants from serotype K1 STL43 and K2 TSGH strains from patients with liver a...